54 Result(s)

Article

Autocrine WNT2 signaling in fibroblasts promotes colorectal cancer progression

The canonical WNT signaling pathway is crucial for intestinal stem cell renewal and aberrant WNT signaling is an early event in colorectal cancer (CRC) development. Here, we show for the first time that WNT2 i...

N Kramer, J Schmöllerl, C Unger, H Nivarthi, A Rudisch, D Unterleuthner… in Oncogene (2017)

Article

Stromal-derived IGF2 promotes colon cancer progression via paracrine and autocrine mechanisms

The insulin-like growth factor (IGF)2/IGF1 receptor (IGF1R) signaling axis has an important role in intestinal carcinogenesis and overexpression of IGF2 is an accepted risk factor for colorectal cancer (CRC) d...

C Unger, N Kramer, D Unterleuthner, M Scherzer, A Burian, A Rudisch, M Stadler… in Oncogene (2017)

Article

IGFBP7, a novel tumor stroma marker, with growth-promoting effects in colon cancer through a paracrine tumor–stroma interaction

The activated tumor stroma participates in many processes that control tumorigenesis, including tumor cell growth, invasion and metastasis. Cancer-associated fibroblasts (CAFs) represent the major cellular com...

C Rupp, M Scherzer, A Rudisch, C Unger, C Haslinger, N Schweifer, M Artaker… in Oncogene (2015)

Article

In vivo evaluation of a novel albumin-binding prodrug of doxorubicin in an orthotopic mouse model of prostate cancer (LNCaP)

PSA, which is overexpressed in prostate carcinoma, represents a molecular target for selectively releasing an anticancer agent from a prodrug formulation. In this study, we report on the in vivo antitumor efficac...

B Elsadek, R Graeser, N Esser, C Schäfer-Obodozie… in Prostate Cancer and Prostatic Diseases (2011)

Article

INNO-206, the (6-maleimidocaproyl hydrazone derivative of doxorubicin), shows superior antitumor efficacy compared to doxorubicin in different tumor xenograft models and in an orthotopic pancreas carcinoma model

The (6-maleimidocaproyl)hydrazone derivative of doxorubicin (INNO-206) is an albumin-binding prodrug of doxorubicin with acid-sensitive properties that is being assessed clinically. The prodrug binds rapidly t...

R. Graeser, N. Esser, H. Unger, I. Fichtner, A. Zhu, C. Unger… in Investigational New Drugs (2010)

Article

Klinische Forschung in der Onkologie

Es geht in der onkologischen Forschung um die Entwicklung neuer Substanzen, um Kombinationen, Ökotrophologie, Psychologie, Datengewinnung, Immunmodulation und Versorgungsforschung. In all diesen Forschungsbere...

Prof. Dr. F.J. Illhardt, C. Unger in Der Onkologe (2009)

Article

A new liposomal formulation of Gemcitabine is active in an orthotopic mouse model of pancreatic cancer accessible to bioluminescence imaging

Despite its rapid enzymatic inactivation and therefore limited activity in vivo, Gemcitabine is the standard drug for pancreatic cancer treatment. To protect the drug, and achieve passive tumor targeting, we d...

C. Bornmann, R. Graeser, N. Esser, V. Ziroli… in Cancer Chemotherapy and Pharmacology (2008)

Article

OuaSelect, a novel ouabain-resistant human marker gene that allows efficient cell selection within 48 h

Efficient selection of gene-modified cells is required for a number of potential gene therapy applications, as well as molecular biology studies. Ideally, a clinical selection regimen would combine high select...

A Treschow, C Unger, A Aints, U Felldin, J Aschan, M S Dilber in Gene Therapy (2007)

Article

Evidence of induced resistance of tomato plants against Phytophthora infestans by a water extract of dried biomass of Penicillium chrysogenum

The water extract of killed Penicillium chrysogenum (Pen) was used to induce resistance against Phytophthora infestans in tomato plants. After two treatments with Pen as foliar spray, a protection of over 90% was...

C. Unger, I. Wilhelm, R. Jünger, R. Thalmann in Journal of Plant Diseases and Protection (2006)

Article

Effect of memantine on the α7 neuronal nicotinic receptors, synaptophysin- and low molecular weight MAP-2 levels in the brain of transgenic mice over-expressing human acetylcholinesterase

Transgenic mice over-expressing human acetylcholinesterase (hAChE-Tg) display memory impairments, cholinergic deficits and reduced dendritic branching. In this study, we found a reduced number of N-Methyl-D-As...

C. Unger, M. M. Svedberg, M. Schutte, I. Bednar… in Journal of Neural Transmission (2005)

Article

Miltefosine (Impavido): the first oral treatment against leishmaniasis

Miltefosine is a novel antileishmanial drug that has significant selectivity in both in vitro and in vivo models. Clinical efficacy was demonstrated for the treatment of visceral leishmaniasis with the advanta...

H. Sindermann, S. L. Croft, K. R. Engel, W. Bommer… in Medical Microbiology and Immunology (2004)

Article

Pflanzliche Zytostatika

Der Überbegriff der pflanzlichen Zytostatika steht für aus Pflanzen oder Pflanzenextrakten gewonnene zytostatisch wirksame Verbindungen. Die Substanzgruppe der klinisch relevanten pflanzlichen Zytostatika umfa...

M. Medinger, C. Unger, J. Drevs in Bundesgesundheitsblatt - Gesundheitsforsch… (2003)

Article

Angiogenesis and the ET-1/ET_A Receptor System: Immunohistochemical Expression Analysis in Bone Metastases from Patients with Different Primary Tumors

Angiogenesis is necessary for the growth of primary tumors and the formation of metastases. It is well known that vascular endothelial growth factor (VEGF) and its receptors play a major role in this process. ...

M. Medinger, C.P. Adler, C. Schmidt-Gersbach, J. Soltau, A. Droll, C. Unger… in Angiogenesis (2003)

Article

Change in pharmacokinetic and pharmacodynamic behavior of gemcitabine in human tumor xenografts upon entrapment in vesicular phospholipid gels

Purpose: The in vivo pharmacokinetics (PK), biodistribution and antitumor activity of a new liposomal formulation of gemcitabine (GemLip) were compared to the conventional (clinical) formulation of gemcitabine (G...

R. Moog, A. Burger, M. Brandl, J. Schüler… in Cancer Chemotherapy and Pharmacology (2002)

Article

Suppressed expression of nicotinic acetylcholine receptors by nanomolar β-amyloid peptides in PC12 cells

A line of evidence has shown that a link between the common pathological features of β-amyloid peptide (Aβ) deposition and cholinergic degeneration observed in Alzheimer's disease (AD) may exist, however, no ...

Z. -Z. Guan, H. Miao, J. -Y. Tian, C. Unger, A. Nordberg… in Journal of Neural Transmission (2001)

Article

Excellent Response to Gemcitabine in a Massively Pre-Treated Woman with Extensive Cutaneous Involvement after Recurrence of Breast Cancer

A 50-year-old woman presented with local relapse ofbreast cancer 6 years after partial mastectomy. Relapse wasaccompanied by extended skin induration due to tumor cellembolization of dermal lymphatics. During ...

J. Arends, C. Unger in Investigational New Drugs (2001)

Chapter

Maligne Tumoren

Krebs ist in den westlichen Industrienationen die zweithäufigste Todesursache nach den Herz-Kreislauf-Erkrankungen: In den USAbetrug 1996 die Anzahl der Krebstoten etwa 530000, in der Bundesrepublik Deutschlan...

C. Unger in Klinische Pharmakologie (2001)

Article

Die Bedeutung von Therapiezielen in der Onkologie

J. Arends, C. Unger in Der Onkologe (1997)