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Open AccessAntipsychotic drug-induced neutropenia: results from the AMSP drug surveillance program between 1993 and 2016
Neutropenia and agranulocytosis (N&A) are relatively rare, but potentially fatal adverse drug reactions (ADR). This study presents cases of N&A related to one or more antipsychotic drugs (APDs) in psychiatric ...
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Article
Open AccessGalactorrhea during antipsychotic treatment: results from AMSP, a drug surveillance program, between 1993 and 2015
Galactorrhea is a well-known adverse drug reaction (ADR) of numerous antipsychotic drugs (APD) and is often distressing for those affected. Methodological problems in the existing literature make it difficult ...
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Article
Depressive Kernsymptome
Unter Kernsymptomen einer Depression versteht man eine Reihe typischer psychischer und somatischer Symptome, die häufig gemeinsam mit psychomotorischen und kognitiven Störungen auftreten. Die aktuelle diagnost...
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Article
Reduced gray matter brain volumes are associated with variants of the serotonin transporter gene in major depression
The serotonergic system is involved in the pathophysiology of major depression as well as in the early central nervous system development and adult neuroplasticity. The aim of the study was to examine in 77 pa...
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Article
Influence of mirtazapine on plasma concentrations of neuroactive steroids in major depression and on 3α-hydroxysteroid dehydrogenase activity
Concentrations of 3α-reduced neuroactive steroids are altered in depression and normalize after antidepressant pharmacotherapy with selective serotonin re-uptake inhibitors (SSRIs). We investigated the impact of ...
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Article
SNP and haplotype analysis of a novel tryptophan hydroxylase isoform (TPH2) gene provide evidence for association with major depression
Tryptophan hydroxylase (TPH), being the rate-limiting enzyme in the biosynthesis of serotonin plays a major role as candidate gene in several psychiatric disorders. Recently, a second TPH isoform (TPH2) was id...
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Article
Effects of Alprazolam on Cholecystokinin-Tetrapeptide-Induced Panic and Hypothalamic–Pituitary–Adrenal-Axis Activity: A Placebo-Controlled Study
Cholecystokinin-tetrapeptide (CCK-4) induces panic attacks both in patients with panic disorder (PD) and healthy volunteers. It has been shown that panic elicited by CCK-4 is improved after treatment with anti...
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Article
Hypericum-perforatum-Extrakt bei der Behandlung leichter bis mittelschwerer Depressionen Klinische und pharmakologische Aspekte
Seit vielen Jahren werden Hyperikumextrakte in der Behandlung depressiver Erkrankungen eingesetzt. Der therapeutische Einsatz dieser Extrakte wurde hierbei lange Zeit vorwiegend mit der klinischen Evidenz ihre...
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Possible influence of the insertion/deletion polymorphism in the angiotensin I-converting enzyme gene on theraputic outcome in affective disorders
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Buspirone and lorazepam in the treatment of generalized anxiety disorder in outpatients
In this double-blind, placebo-controlled 10-week trial, the anxiolytic properties of the nonbenzodiazepine buspirone were compared with the benzo diazepine lorazepam and placebo in 125 outpatients with genera...