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Article
Directionality of non-permissive HLA-DPB1 T-cell epitope group mismatches does not improve clinical risk stratification in 8/8 matched unrelated donor hematopoietic cell transplantation
In 8/8 HLA-matched unrelated donor (UD) hematopoietic cell transplants (HCT), HLA-DPB1 mismatches between alleles from different T-cell epitope (TCE) groups (non-permissive mismatches) are associated with sign...
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Article
YKL-40 in allogeneic hematopoietic cell transplantation after AML and myelodysplastic syndrome
YKL-40, also called chitinase-3-like-1 protein, is an inflammatory biomarker that has been associated with disease severity in inflammatory and malignant diseases, including AML, multiple myeloma and lymphomas...
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Article
Allogeneic hematopoietic cell transplantation as curative therapy for non-transformed follicular lymphomas
Allogeneic hematopoietic cell transplantation (HCT) offers the chance of cure for patients with non-transformed follicular lymphoma (FL), but is associated with the risk of non-relapse mortality (NRM). The aim...
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Article
Related hematopoietic cell donor care: is there a role for unrelated donor registries?
In almost half of allogeneic hematopoietic progenitor cell (HPC) transplants, a related donor (RD) is used, yet a lack of standardized guidelines means that their care is heterogeneous. Changes to regulatory s...
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Article
3D visualization of the regional differences
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Article
Clustering autism: using neuroanatomical differences in 26 mouse models to gain insight into the heterogeneity
Autism is a heritable disorder, with over 250 associated genes identified to date, yet no single gene accounts for >1–2% of cases. The clinical presentation, behavioural symptoms, imaging and histopathology fi...
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Article
ATR controls cellular adaptation to hypoxia through positive regulation of hypoxia-inducible factor 1 (HIF-1) expression
Tumor cells adaptation to severe oxygen deprivation (hypoxia) plays a major role in tumor progression. The transcription factor HIF-1 (hypoxia-inducible factor 1), whose α-subunit is stabilized under hypoxic c...
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Article
Urinary NT-proBNP and ductal closure in preterm infants
To explore the association of urinary N-terminal pro-brain natriuretic peptide (NT-proBNP) concentrations and closure of patent ductus arteriosus (PDA) in preterm infants.
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Article
Information technology and the role of WMDA in promoting standards for international exchange of hematopoietic stem cell donors and products
Nearly half of the unrelated hematopoietic SCTs facilitated worldwide involves an exchange of products between countries. The process is information intensive and requires coordination through regional hubs of...
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Article
Cord blood banks collect units with different HLA alleles and haplotypes to volunteer donor banks: a comparative report from Swiss Blood stem cells
Allogeneic haematopoietic SCT is a standard therapy for many patients with haematological diseases. A major aim of public umbilical cord blood (UCB) banking is to establish an inventory with a large HLA divers...
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Article
Novel renal replacement strategies for the elimination of serum free light chains in patients with kappa light chain nephropathy
Multiple myeloma (MM) is a malignancy with excessive production of monoclonal proteins. At disease presentation 30% of MM patients have significant renal impairment which may progress to renal failure requirin...
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Article
Acid sphingomyelinase deficiency protects from cisplatin-induced gastrointestinal damage
Cisplatin is one of the most effectively used chemotherapeutic agents for cancer treatment. However, in humans, important cytotoxic side effects are observed including dose-limiting renal damage and profound g...
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Article
Erratum: Incorporation of the bone marker carboxy-terminal telopeptide of type-1 collagen improves prognostic information of the International Staging System in newly diagnosed symptomatic multiple myeloma
Correction to: Leukemia (2008) 22, 1767–1772; doi:10.1038/leu.2008.159; published online 26 June 2008 Since the publication of their paper, the authors have identified an error in the 5-year overall survival r...
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Article
Incorporation of the bone marker carboxy-terminal telopeptide of type-1 collagen improves prognostic information of the International Staging System in newly diagnosed symptomatic multiple myeloma
Several prognostic markers, including parameters of tumor burden and cytogenetics, were adopted to identify high-risk patients in multiple myeloma (MM). Recently, the International Staging System (ISS), includ...
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Article
158 Materno-Fetal Transfer of 125-I-Leptin in The Dual in vitro Perfused Placenta Perfusion Model and Increased Leptin Mrna-Expression in Adipose Tissue of Pregnant Women
Background: Leptin is a growth factor for the fetus. The sources for maternal and fetal leptin plasma levels are the adipose tissue and the placenta. Placental leptin release elevates maternal leptin levels only ...
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Article
A special report: suggested procedures for international unrelated donor search from the donor registries and quality assurance working groups of the World Marrow Donor Association (WMDA)
This special report details the World Marrow Donor Association's recommended procedures regarding the international search for an unrelated donor for hematopoietic stem cell transplantation. The responsibiliti...
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Article
Donor and liability insurance of donor registries, donor centers, and collection centers – recommendations
The article presents views and recommendations of the World Marrow Donor Association regarding the need for donor and liability insurance for hematopoietic stem cell donor registries, and donor and collection ...
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Article
Treatment of HBV-carrying lymphoma patients with Rituximab and CHOP: a diagnostic and therapeutic challenge
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Article
Assessment of Microcirculation in VLBW infants by near infra red and red photoplethysmography (NIRP)
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Article
Acute myeloid leukemia cells with low P-glycoprotein expression and high Rhodamine 123 efflux capacity display high clonogenicity
This study was designed to correlate the clonogenic capacity of acute myeloid leukemia (AML) cells with P-glycoprotein (P-gp) expression level and P-gp-mediated efflux capacity. Fifty AML cell samples were tes...