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Article
Open AccessConversion of unresponsiveness to immune checkpoint inhibition by fecal microbiota transplantation in patients with metastatic melanoma: study protocol for a randomized phase Ib/IIa trial
The gut microbiome plays an important role in immune modulation. Specifically, presence or absence of certain gut bacterial taxa has been associated with better antitumor immune responses. Furthermore, in tria...
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Article
Open AccessA real or apparent decrease in glomerular filtration rate in patients using olaparib?
Olaparib is a poly (ADP-ribose) polymerase (PARP) inhibitor indicated for ovarian and metastatic breast cancer. Increased serum creatinine levels have been observed in patients taking olaparib, but the underly...
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Article
Open AccessDiscontinuation of proton pump inhibitors during assessment of chromogranin A levels in patients with neuroendocrine tumours
The aim of this prospective study was to examine whether discontinuation of proton pump inhibitors (PPIs) or replacement by H2-receptor antagonists (H2RA) resulted in a decrease of chromogranin A (CgA) levels in ...
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Article
Open AccessRole of natriuretic peptides in the diagnosis and treatment of patients with carcinoid heart disease
Carcinoid heart disease (CHD) occurs in 20–70% of the patients with metastatic well-differentiated neuroendocrine tumours (NET). We evaluated whether natriuretic peptides (ANP or NT-proBNP) are useful in early...
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Article
Open AccessReactivity to human papillomavirus type 16 L1 virus-like particles in sera from patients with genital cancer and patients with carcinomas at five different extragenital sites
A retrospective seroepidemiologic study was performed to examine the association between human papillomaviruses (HPV) 16 infection and carcinomas of the oropharynx, the oesophagus, penis and vagina. Sera were ...
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Chapter and Conference Paper
Monitoring Malignant Melanoma with the S-100B Tumour Marker
To assess the usefulness of the S-100B tumour marker in monitoring therapy and during follow-up we measured S-100B serum concentration in 31 patients participating in a phase I trial studying the effect of vac...
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Chapter
Prognostic Significance of Antibodies to HPV-16 E7 /E4 Proteins and Fragments of Cytokeratin 19 in Invasive Cervical Carcinoma
The objective of this study was to search for new markers with prognostic potential. in invasive carcinoma of the uterine cervix. Sera of 78 patients with cervical. cancer were tested for the presence of Ig-G ...
