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    A phase I, dose-escalation study of the Eg5-inhibitor EMD 534085 in patients with advanced solid tumors or lymphoma

    Background The kinesin spindle protein Eg5 is involved in mitosis, and its inhibition promotes mitotic arrest. EMD 534085, a potent, reversible Eg5 inhibitor, demonstrated significant pre...

    A. Hollebecque, E. Deutsch, C. Massard, C. Gomez-Roca… in Investigational New Drugs (2013)