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Article
Defective immunogenic cell death of HMGB1-deficient tumors: compensatory therapy with TLR4 agonists
Immunogenic cell death induced by anticancer chemotherapy is characterized by a series of molecular hallmarks that include the exodus of high-mobility group box 1 protein (HMGB1) from dying cells. HMGB1 is a n...
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Article
Open AccessCounterattack – a principle of tumour cell metastasation?
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Article
Haut
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Article
Influence of EDTA and heparin on lipopolysaccharide binding, internalization, and cell activation, evaluated at single-cell level in whole blood
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Article
Dose-dependence of bacterial lipopolysaccharide (LPS) effects on peak response and time course of the immune-endocrine host response in humans
Objective and Design: Dose-dependence of lipopolysaccharide (LPS) effects on peak and time course parameters of the immune-endocrine host response was examined in a placebo-controlled de...
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Chapter and Conference Paper
Effekte von Paramunitätsinducern auf die Übelebensrate und Leukozyten/Endothel-Interaktion bei muriner Endotoxinämie
Die Sequestration von Leukozyten in das perivaskuläre Gewebe wird über spezifische Adhäsionsmechanismen vermittelt [1]. Therapeutische Blockade der Adhärenz durch Antikörper gegen Integrine (CD11b/CD18) oder g...
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Chapter and Conference Paper
Effekte von Adenosin auf die intravasale Akkumulation von Leukozyten und den Gewebeschaden im quergestreiften Muskel bei Endotoxinämie
Untersuchungen aus unserem Labor haben gezeigt, daß die durch Endotoxin induzierte Sequestration von Leukozyten in das perivaskuläre Gewebe des quergestreiften Muskels über spezifische Adhäsionsmechanismen med...
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Chapter and Conference Paper
Blockade von Plättchen-Endothelzell-Adhäsionsmolekül-1 (PECAM-1, CD31) vermindert das durch Endotoxin induzierte mikrovaskuläre Leak-Syndrom im quergestreiften Muskel bei der BALB/c Maus
Die durch Endotoxin induzierte Sequestration von Leukozyten in das perivaskuläre Gewebe ist verbunden mit gesteigerter Extravasation von Plasma in den perivaskulären Raum (mikrovaskuläres Leak-Syndrom). Der er...
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Article
Biochemical characterization of lipopolysaccharides extracted from a hydrophobic strain of Pasteurella multocida
Lipopolysaccharides were extracted from freeze-dried cells of Pasteurella multocida strain P-1581 (serotype 8) by the phenol-chloroform-petroleum ether method and biochemically analysed using standard procedures....
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Chapter and Conference Paper
Monoklonale Antikörper gegen P- und E-Selektin zur therapeutischen Beeinflussung der Leukozytensequestration im quergestreiften Muskel nach Endotoxinämie in der Balb/c-Maus
Die durch Endotoxin induzierte Sequestration von Leukozyten ist von zentraler Bedeutung für die Propagation des septischen Krankheitsbildes und die Pathogenese des multiplen Organversagens. Endotoxin führt übe...
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Article
Function and “homing” of the lung macrophages
The object of the present investigation was to extend fundamental understanding of the composition, function and origin of bronchoalveolar lavage (BAL) cells, and to reduce the considerable gaps in our existin...
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Article
The role of macrophages in the uptake of endotoxin by the mouse liver
The purpose of this investigation was to analyse the macrophage subpopulations involved in the uptake of endotoxin in the liver.
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Chapter
Metabolic Fate of Endotoxin in Rat
Endotoxins (lipopolysaccharide, LPS) of gram-negative bacteria induce numerous biological activities which, depending on concentration of endotoxin and reactivity of the host may be either harmful or beneficia...
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Chapter
Mechanisms of the Lethal Action of Endotoxin and Endotoxin Hypersensitivity
Endotoxins (lipopolysaccharides, LPS) are endowed with a vast spectrum of biological activities that are both harmful and beneficiary for the host-organism. Many of these activities, e.g., mitogenic and polycl...
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Article
Mechanism of replacement of non-parenchymal liver cells (NPLC) in murine radiation chimeras
The mechanism of cell replacement of non-parenchymal liver cells (NPLC) was investigated in an attempt to answer the question: to what extend are NPLC replaced by proliferation of local resident cells and to w...
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Article
Identification and percentage frequency of isolated non-parenchymal liver cells (NPLC) in the mouse
The aim of the present study was to identify non-parenchymal liver cells (NPLC) in B10.D2 mice and to determine their percentage frequency. The isolation of NPLC was carried out using the collagenase/pronase t...
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Article
Evaluation of procoagulant activity production and other coagulative functions in cancer patients receiving acid treated Salmonella minnesota R 595 (Re)
Blood clotting parameters were measured in six patients with gynecologic tumors following i.v. administration of acetic acid-treated Salmonella minnesota R595 (Re), which has been previously demonstrated to enhan...
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Article
Bacterial endotoxins
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Article
Investigations into the origin of mouse liver sinusoidal cells
The possibility that liver sinusoidal cells are derived from the bone-marrow was investigated in chimeric mice. H2k-positive bone-marrow cells from F1 (B10.BR × B10.D2) hybrid mice were transplanted into irradiat...
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Chapter and Conference Paper
Lipid A und Anti-Lipid-A — Strukturen, Eigenschaften und Wirkungsmechanismen
Man weiß seit mehr als 100 Jahren, daß die Freisetzung von Komponenten der Bakterienoberfläche in enger Beziehung zu vielen pathophysiologischen Reaktionen des Organismus bei gramnegativen Infektionen steht. D...
