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  1. No Access

    Article

    Abstracts of poster presentations

    A. B. Agostinho, F. Rosi, A. Tabucchi, F. Carlucci… in Pharmacy World and Science (1993)

  2. No Access

    Article

    Paternal origin of new mutations in Von Recklinghausen neurofibromatosis

    VON Recklinghausen neurofibromatosis (NF-1)1–4 is a common autosomal dominant disorder. The estimated new mutation rate (1 x 10−4) is one of the highest for a human disorder1. Here we report that in 12 of 14 fam...

    D. Jadayel, P. Fain, M. Upadhyaya, M. A. Ponder, S. M. Huson, J. Carey, A. Fryer… in Nature (1990)

  3. No Access

    Article

    Early diagnosis of multiple endocrine neoplasia type IIa

    We report on incidental findings during family screening of two kindreds with multiple endocrine neoplasia type IIa. Pheochromocytoma and medullary thyroid carcinoma of considerable size were detected. The res...

    H. P. H. Neumann, O. A. Müller, B. A. J. Ponder, C. G. P. Mathew… in Klinische Wochenschrift (1989)

  4. No Access

    Article

    A linked genetic marker for multiple endocrine neoplasia type 2A on chromosome 10

    Multiple endocrine neoplasia type 2A (MEN2A) is an autosomal dominantly inherited cancer syndrome characterized by medullary carcinoma of the thyroid, phaeochromocytoma and hyperparathyroidism. Almost all gen...

    C. G. P. Mathew, K. S. Chin, D. F. Easton, K. Thorpe, C. Carter, G. I. Liou… in Nature (1987)

  5. No Access

    Article

    Deletion of genes on chromosome 1 in endocrine neoplasia

    Recent studies have identified normal cellular DNA sequences which are lost in the development of embryonal1–6 and adult7,8 tumours. These tumours are thought to arise after a primary mutation in one allele of s...

    C. G. P. Mathew, B. A. Smith, K. Thorpe, Z. Wong, N. J. Royle, A. J. Jeffreys… in Nature (1987)

  6. No Access

    Protocol

    The Isolation of High Molecular Weight Eukaryotic DNA

    The isolation of high molecular weight eukaryotic DNA in good yield is an important prerequisite for the analysis of specific sequences by Southern blotting (Chapter 9

    C. G. P. Mathew in Nucleic Acids (1984)

  7. No Access

    Protocol

    Radiolabeling of DNA by Nick Translation

    Nick translation is the name given to a reaction that is used to replace cold nucleoside triphosphates in a double-stranded DNA molecule with radioactive ones (1,2). Free 3′-hydroxyl groups are created within the...

    C. G. P. Mathew in Nucleic Acids (1984)

  8. No Access

    Protocol

    Detection of Specific DNA Sequences—The Southern Transfer

    The purpose of this technique is the detection and characterization of specific DNA sequences. The DNA is fragmented by digestion with a restriction endonuclease, and the fragments separated by agarose gel ele...

    C.G.P. Mathew in Nucleic Acids (1984)

  9. Article

    AChE uses

    R.G. ELLES, T.R. SKERN, M.E.E. HILL, J.E. ARRAND, D.A. WESTAWAY, C.G.P. MATHEW… in Nature (1980)

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