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Complete mesocolic excision versus standard resection for colon cancer: a systematic review and meta-analysis of perioperative safety and an evaluation of the use of a robotic approach
Complete mesocolic excision (CME) has been associated with improved oncological outcomes in treatment of colon cancer. However, widespread adoption is limited partly because of the technical complexity and per...
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Open AccessRandomized trial comparing low-pressure versus standard-pressure pneumoperitoneum in laparoscopic colectomy: PAROS trial
Laparoscopy, by its minimally invasive nature, has revolutionized digestive and particularly colorectal surgery by decreasing post-operative pain, morbidity, and length of hospital stay. In this trial, we aim ...
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Article
Are dental students well-equipped to deal with difficult communication situations?
Identifies clinical dental students' levels of confidence in a range of communication scenarios to assist in highlighting areas requiring further attention.
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Targeted de-escalation rounds may effectively and safely reduce meropenem use
Use of meropenem in our hospital has doubled in recent years. An audit in 2013 showed that although initiation of therapy with meropenem was generally appropriate, therapy was rarely subsequently reviewed and ...
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Article
Open AccessA pilot study demonstrating the altered gut microbiota functionality in stable adults with Cystic Fibrosis
Cystic Fibrosis (CF) and its treatment result in an altered gut microbiota composition compared to non-CF controls. However, the impact of this on gut microbiota functionality has not been extensively characte...
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Endocrine therapy adherence: a cross-sectional study of factors affecting adherence and discontinuation of therapy
Adjuvant endocrine therapy for at least 5 years improves oncological outcomes in oestrogen receptor-positive breast cancer. Adherence rates to prescribed endocrine therapy are low and the search for modifiable...
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Draining the pus
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Open AccessNT5E (CD73) is epigenetically regulated in malignant melanoma and associated with metastatic site specificity
Novel prognostic biomarkers and therapeutic strategies are urgently required for malignant melanoma. Ecto-5-prime-nucleotidase (NT5E; CD73) overexpression has been reported in several human cancers. The mechanism...
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Article
Generalised tetanus in an unvaccinated adult
A 76-year-old previously well farmer presented having caught his left index finger in a gate. He gave no history of prior tetanus vaccination. The patient was treated in the emergency department; the wound cle...
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Open AccessTherapeutic drug monitoring of new formulation Kaletra in pregnancy
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Irish Association for Cancer Research
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Social and Individual Significance of Ageing