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  1. No Access

    Article

    A novel Alzheimer disease locus located near the gene encoding tau protein

    APOE ɛ4, the most significant genetic risk factor for Alzheimer disease (AD), may mask effects of other loci. We re-analyzed genome-wide association study (GWAS) data from the International Genomics of Alzheimer’...

    G Jun, C A Ibrahim-Verbaas, M Vronskaya, J-C Lambert, J Chung… in Molecular Psychiatry (2016)

  2. No Access

    Article

    Association of Alzheimer’s related genotypes with cognitive decline in multiple domains: results from the Three-City Dijon study

    Several genetic polymorphisms have been associated with Late Onset Alzheimer’s Disease (LOAD), but there has been limited evidence on whether these polymorphisms predict intermediary stage outcomes such as cog...

    A Vivot, M M Glymour, C Tzourio, P Amouyel, G Chêne, C Dufouil in Molecular Psychiatry (2015)

  3. Article

    Open Access

    Genetic contributions to variation in general cognitive function: a meta-analysis of genome-wide association studies in the CHARGE consortium (N=53 949)

    General cognitive function is substantially heritable across the human life course from adolescence to old age. We investigated the genetic contribution to variation in this important, health- and well-being-r...

    G Davies, N Armstrong, J C Bis, J Bressler, V Chouraki, S Giddaluru… in Molecular Psychiatry (2015)

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  4. No Access

    Article

    Évaluation des traitements non médicamenteux dans la maladie d’Alzheimer

    Bien que leur efficacité n’ait pas souvent été étudiée et de surcroît démontrée, les traitements non médicamenteux font partie intégrante de la prise en charge des personnes atteintes de démence neurodégénérat...

    N. Coley, C. Dufouil, M. Bungener, N. Bouscaren… in Les cahiers de l'année gérontologique (2013)

  5. Article

    Open Access

    P3.03 Arterial Stiffness is Associated with a Higher Risk of Extend Periventricular and Deep White Matter Lesions According to Gender in Elderly

    White matter lesions (WMLs) are detected on brain MRI of elderly and are predictive of cognitive decline. Arterial stiffness is a cause of systolic hypertension and of increase in central pressure and might pr...

    C. Collin, M. Revera, B. Mazoyer, S. Laurent, C. Tzourio, P. Boutouyrie… in Artery Research (2010)

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  6. Article

    Open Access

    P4.04 Long-Term Reduction in Aortic Stiffness in Hypertensive Patients is Partly Independent of Mbp Reduction

    A decrease in aortic stiffness could theoretically occur after several years of treatment but reduction has never been unequivocally demonstrated in clinical practice. Association with changes in blood pressur...

    C. Collin, H. Ait-Oufella, K. T. Ong, H. Beaussier, E. Bozec, C. Dufouil… in Artery Research (2009)

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  7. Article

    Cognitive function and risks of cardiovascular disease and hypoglycaemia in patients with type 2 diabetes: the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified Release Controlled Evaluation (ADVANCE) trial

    The relationship between cognitive function, cardiovascular disease and premature death is not well established in patients with type 2 diabetes. We assessed the effects of cognitive function in 11,140 patient...

    B. E. de Galan, S. Zoungas, J. Chalmers, C. Anderson, C. Dufouil, A. Pillai… in Diabetologia (2009)

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  8. No Access

    Chapter and Conference Paper

    The Implications of Epidemiological Findings for the Prevention of Alzheimer’s Disease

    The greatest burden of dementia in the population is in age groups that have shown a marked increase in recent decades, mainly those aged 80 to 84 and mainly women. This rise is due to the increase in the prev...

    C. Brayne, C. Dufouil, M. A. McGee in Epidemiology of Alzheimer’s Disease: From … (1999)