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Open AccessPrevention and early treatment of the long-term physical effects of COVID-19 in adults: design of a randomised controlled trial of resistance exercise—CISCO-21
Coronavirus disease-19 (COVID-19) infection causes persistent health problems such as breathlessness, chest pain and fatigue, and therapies for the prevention and early treatment of post-COVID-19 syndromes are...
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Article
Modulation of the Renin-Angiotensin-Aldosterone System in Heart Failure
The renin-angiotensin-aldosterone system (RAAS) is well-established and continues to be pursued as a therapeutic target in the treatment of heart failure, predominantly due to the success of agents that block ...
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Article
Dysglycaemia and the risk of acute myocardial infarction in multiple ethnic groups: an analysis of 15,780 patients from the INTERHEART study
Although diabetes is an established risk factor for myocardial infarction (MI), disease control may vary. HbA1c is a reliable index of ambient glucose levels and may provide more information on MI risk than diabe...
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Article
The prognostic value of the ECG in hypertension: where are we now?
In hypertension, the presence of left ventricular hypertrophy (LVH) is associated with increased risk of both cardiovascular morbidity and mortality. To date, the electrocardiogram (ECG) remains the cornerston...
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Article
On the origin of the wide HI absorption line towards Sgr A*
We have imaged a region of ∼ 5′ extent surrounding Sgr A* in the HI 21 cm-line absorption using the Very Large Array. A Gaussian decomposition of the optical depth spectra at positions within ∼ 2′ (∼ 5 pc at 8...
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Article
A faint discrete source origin for the highly ionized iron emission from the Galactic Centre region
The origin of the X-ray emission for the central region of our Galaxy has remained a mystery1,2,3,4. In particular, the relative spectral contributions of the diffuse emission and discrete sources, which are crit...
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Article
Effects of lisinopril on congestive heart failure in normotensive patients with diastolic dysfunction but intact systolic function
This study examined the effects of lisinopril on diastolic function in 12 normotensive patients (mean age 72 years) with symptomatic congestive heart failure, intact left ventricular systolic function and abno...
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Article
Raised plasma levels of atrial natriuretic factor in cardiac allograft recipients: evidence of increased cardiac secretion and decreased renal clearance
The mechanism(s) causing high levels of plasma atrial natriuretic factor (ANF) in cardiac allograft recipients is(are) unclear. The kidney is important for the clearance of ANF and renal function may decline w...
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Article
Effect of atrial natriuretic factor on platelet function in whole blood ex-vivo in man
Atrial natriuretic factor (ANF) binding sites have been shown to be present on human platelet membranes. We investigated the effect of an infusion of ANF 5 pmol·kg−1.min−1 on platelet aggregation in whole blood e...