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  1. No Access

    Chapter

    Genetics, molecular biology, and animal modeling of Alzheimer’s disease

    P. H. St George-Hyslop, P. E. Fraser, D. Westaway… in Alzheimer: 100 Years and Beyond (2006)

  2. No Access

    Article

    Modeling of a periodic instability in paired helical filaments reveals an axial repeat

    Ultrastructural studies of paired helical filaments (PHF) have been facilitated by the ability to isolate enriched fractions of detergent-insoluble forms of PHF. These fractions are composed of a relatively h...

    M. S. Pollanen, C. Bergeron in Acta Neuropathologica (2000)

  3. No Access

    Chapter

    Presenilin Proteins and the Pathogenesis of Early-Onset Familial Alzheimer’s Disease: β-Amyloid Production and Parallels to Prion Diseases

    In contrast to rare mutations in the amyloid presursor protein (APP) gene, missense mutations in the presenilin 1 (PS1) and presenilin 2 (PS2) genes, on chromosomes 14 and 1 respectively, are the most common c...

    D. Westaway, G. A. Carlson, C. Bergeron… in Prions and Brain Diseases in Animals and H… (1998)

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    Article

    Alzheimer paired helical filaments: a comparison with the twisted ribbon model

    To investigate if Alzheimer paired helical filaments (PHF) closely resemble twisted ribbons, as indicated by recent high-resolution ultrastructural studies, we compared physical models of twisted ribbons with ...

    M. S. Pollanen, P. Markiewicz, M. C. Goh, C. Bergeron in Acta Neuropathologica (1995)

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    Article

    Characterization of a shared epitope in cortical Lewy body fibrils and Alzheimer paired helical filaments

    The straight fibrils of the Lewy body contain an epitope related to phosphorylation of the KSPV motif common to the C termini of the 200- and 170-kDa neurofilament subunits and τ. To further characterize this ...

    M. S. Pollanen, C. Bergeron, L. Weyer in Acta Neuropathologica (1994)

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    Article

    Absence of protease-resistant prion protein in dementia characterized by neuronal loss and status spongiosus

    Dementia characterized by neuronal loss and status spongiosus (DNLS) is a non-Alzheimer degenerative process which is characterized by Pick-like lobar atrophy with neuronal depletion and gliosis of the cerebra...

    M. S. Pollanen, C. Bergeron, L. Weyer in Acta Neuropathologica (1993)

  7. No Access

    Article

    Hereditary diabetes insipidus: an immunohistochemical study of the hypothalamus and pituitary gland

    We report the histological findings in a case of hereditary diabetes insipidus (HDI) using vasopressin (VP) immunohistochemistry. The hypothalamus displayed a marked loss of magnocellular VP neurons, with pres...

    C. Bergeron, K. Kovacs, C. Ezrin, C. Mizzen in Acta Neuropathologica (1991)