![Loading...](https://link.springer.com/static/c4a417b97a76cc2980e3c25e2271af3129e08bbe/images/pdf-preview/spacer.gif)
-
Article
Open AccessPan-cancer analysis of genomic scar patterns caused by homologous repair deficiency (HRD)
Homologous repair deficiency (HRD) is present in many cancer types at variable prevalence and can indicate response to platinum-based chemotherapy and PARP inhibition. We developed a tumor classification syste...
-
Article
Open AccessAssociation of PHB 1630 C>T and MTHFR 677 C>T polymorphisms with breast and ovarian cancer risk in BRCA1/2 mutation carriers: results from a multicenter study
The variable penetrance of breast cancer in BRCA1/2 mutation carriers suggests that other genetic or environmental factors modify breast cancer risk. Two genes of special interest are prohibitin (PHB) and methyle...
-
Article
Cerebellar stem cells act as medulloblastoma-initiating cells in a mouse model and a neural stem cell signature characterizes a subset of human medulloblastomas
Cells with stem cell properties have been isolated from various areas of the postnatal mammalian brain, most recently from the postnatal mouse cerebellum. We show here that inactivation of the tumor suppressor...
-
Article
Open AccessThe TP53 Arg72Pro and MDM2 309G>T polymorphisms are not associated with breast cancer risk in BRCA1 and BRCA2 mutation carriers
The TP53 pathway, in which TP53 and its negative regulator MDM2 are the central elements, has an important role in carcinogenesis, particularly in BRCA1- and BRCA2-mediated carcinogenesis. A single nucleotide pol...
-
Article
A ‘Nonsense’ Mutation Leads to Aberrant Splicing of hMLH1 in a German Hereditary Non-polyposis Colorectal Cancer Family
Hereditary Non-polyposis Colorectal Cancer (HNPCC) is an autosomal dominant cancer predisposition syndrome caused by germline mutations in at least four genes encoding integral components of the cellular DNA m...
-
Article
Glioblastoma multiforme als Manifestation des Turcot-Syndroms
-
Article
The reliability of immunohistochemistry as a prescreening method for the diagnosis of hereditary nonpolyposis colorectal cancer (HNPCC) – Results of an international collaborative study
Hereditary nonpolyposis colorectal cancer syndrome (HNPCC) is an autosomal dominant condition accounting for 2–5% of all colorectal carcinomas as well as a small subset of endometrial, upper urinary tract and ...
-
Chapter and Conference Paper
Growth studies of hetero-epitaxial thin films with x-rays
Heteroepitaxial growth of lanthanide-metal films on W(110) was investigated with x rays. Lanthanide-metal films growth with high crystalline quality, revealing extended growth oscillations in the specularly re...
-
Chapter and Conference Paper
Beeinflussung der operativen Strategie beim HNPCC durch molekulare und klinische Aspekte
Because of the positive correlation between Amsterdam criteria and positive MSI analysis, a subtotal colectomy with ileorectal anastomosis seems to be indicated in patients with positive Amsterdam criteria to ...
-
Chapter and Conference Paper
HNPCC: Schwierigkeiten einer klinischen Definition und Herausforderung an die Molekularbiologie
Beim HNPCC (Hereditary Non-Polyposis Colorectal Cancer, Lynch Syndrom) handelt es sich um eine autosomal dominante Tumorprädisposition [1]. In den betroffenen Familien treten neben kolorektalen Karzinomen über...
-
Article
Investigations of the presence of human papilloma virus (HPV) type 16 DNA in solar keratoses: Another possible cancer risk factor in concert with elevated P53 protein expression?
-
Article
P53 levels are elevated in diverse precancerous epidermal lesions, solid carcinomas, and chronically sun-expeosed epidermis
-
Article
Aquatic mosses for the detection and follow-up of accidental discharges in surface waters
Aquatic mosses have been used to study four accidental discharges of the heavy metals Cd, Zn and Hg or the chlorinated hydrocarbons pentachlorophenol (PCP) and lindane in highly contrasting river types. Hg, PC...
-
Article
Supplement II: Abstracts of the international symposium on Skin Carcinogenesis in man and in experimental models. Heidelberg, 29–31 October 1991 (pp S61–S88)
-
Article
Intrafamiliar long-time epidemiology of drug-resistance factors and other plasmids in fecalE. coli