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  1. Article

    Open Access

    Pan-cancer analysis of genomic scar patterns caused by homologous repair deficiency (HRD)

    Homologous repair deficiency (HRD) is present in many cancer types at variable prevalence and can indicate response to platinum-based chemotherapy and PARP inhibition. We developed a tumor classification syste...

    E. Rempel, K. Kluck, S. Beck, I. Ourailidis, D. Kazdal in npj Precision Oncology (2022)

  2. Article

    Open Access

    Association of PHB 1630 C>T and MTHFR 677 C>T polymorphisms with breast and ovarian cancer risk in BRCA1/2 mutation carriers: results from a multicenter study

    The variable penetrance of breast cancer in BRCA1/2 mutation carriers suggests that other genetic or environmental factors modify breast cancer risk. Two genes of special interest are prohibitin (PHB) and methyle...

    A Jakubowska, D Rozkrut, A Antoniou, U Hamann, R J Scott in British Journal of Cancer (2012)

  3. No Access

    Article

    Cerebellar stem cells act as medulloblastoma-initiating cells in a mouse model and a neural stem cell signature characterizes a subset of human medulloblastomas

    Cells with stem cell properties have been isolated from various areas of the postnatal mammalian brain, most recently from the postnatal mouse cerebellum. We show here that inactivation of the tumor suppressor...

    R Sutter, O Shakhova, H Bhagat, H Behesti, C Sutter, S Penkar, A Santuccione in Oncogene (2010)

  4. Article

    Open Access

    The TP53 Arg72Pro and MDM2 309G>T polymorphisms are not associated with breast cancer risk in BRCA1 and BRCA2 mutation carriers

    The TP53 pathway, in which TP53 and its negative regulator MDM2 are the central elements, has an important role in carcinogenesis, particularly in BRCA1- and BRCA2-mediated carcinogenesis. A single nucleotide pol...

    O M Sinilnikova, A C Antoniou, J Simard, S Healey, M Léoné in British Journal of Cancer (2009)

  5. No Access

    Article

    A ‘Nonsense’ Mutation Leads to Aberrant Splicing of hMLH1 in a German Hereditary Non-polyposis Colorectal Cancer Family

    Hereditary Non-polyposis Colorectal Cancer (HNPCC) is an autosomal dominant cancer predisposition syndrome caused by germline mutations in at least four genes encoding integral components of the cellular DNA m...

    J. Baehring, C. Sutter, M. Kadmon, M. V. Knebel Doeberitz, J. Gebert in Familial Cancer (2006)

  6. No Access

    Article

    Glioblastoma multiforme als Manifestation des Turcot-Syndroms

    E. Grips, N. Wentzensen, C. Sutter, O. Sedlaczek, J. Gebert, R. Weigel in Der Nervenarzt (2002)

  7. No Access

    Article

    The reliability of immunohistochemistry as a prescreening method for the diagnosis of hereditary nonpolyposis colorectal cancer (HNPCC) – Results of an international collaborative study

    Hereditary nonpolyposis colorectal cancer syndrome (HNPCC) is an autosomal dominant condition accounting for 2–5% of all colorectal carcinomas as well as a small subset of endometrial, upper urinary tract and ...

    Wolfram Müller, Lawrence J. Burgart, Ruth Krause-Paulus in Familial Cancer (2001)

  8. No Access

    Chapter and Conference Paper

    Growth studies of hetero-epitaxial thin films with x-rays

    Heteroepitaxial growth of lanthanide-metal films on W(110) was investigated with x rays. Lanthanide-metal films growth with high crystalline quality, revealing extended growth oscillations in the specularly re...

    E. Weschke, C. Schüßler-Langeheine, R. Meier in Advances in Solid State Physics 39 (1999)

  9. No Access

    Chapter and Conference Paper

    Beeinflussung der operativen Strategie beim HNPCC durch molekulare und klinische Aspekte

    Because of the positive correlation between Amsterdam criteria and positive MSI analysis, a subtotal colectomy with ileorectal anastomosis seems to be indicated in patients with positive Amsterdam criteria to ...

    H.-P. Wüllenweber, C. Sutter, M. Kadmon in Vielfalt und Einheit der Chirurgie Humanit… (1998)

  10. No Access

    Chapter and Conference Paper

    HNPCC: Schwierigkeiten einer klinischen Definition und Herausforderung an die Molekularbiologie

    Beim HNPCC (Hereditary Non-Polyposis Colorectal Cancer, Lynch Syndrom) handelt es sich um eine autosomal dominante Tumorprädisposition [1]. In den betroffenen Familien treten neben kolorektalen Karzinomen über...

    Dr. M. Kadmon, B. Leichtweis, J. Gebert in Chirurgisches Forum ’97 für experimentelle… (1997)

  11. No Access

    Article

    Investigations of the presence of human papilloma virus (HPV) type 16 DNA in solar keratoses: Another possible cancer risk factor in concert with elevated P53 protein expression?

    C. Sutter, A. Behrens, M. Varnai in Journal of Cancer Research and Clinical On… (1995)

  12. No Access

    Article

    P53 levels are elevated in diverse precancerous epidermal lesions, solid carcinomas, and chronically sun-expeosed epidermis

    C. Sutter, M. Varnai, J. Friemann in Journal of Cancer Research and Clinical Oncology (1995)

  13. No Access

    Article

    Aquatic mosses for the detection and follow-up of accidental discharges in surface waters

    Aquatic mosses have been used to study four accidental discharges of the heavy metals Cd, Zn and Hg or the chlorinated hydrocarbons pentachlorophenol (PCP) and lindane in highly contrasting river types. Hg, PC...

    C. Mouvet, E. Morhain, C. Sutter, N. Couturieux in Water, Air, and Soil Pollution (1993)

  14. No Access

    Article

    Supplement II: Abstracts of the international symposium on Skin Carcinogenesis in man and in experimental models. Heidelberg, 29–31 October 1991 (pp S61–S88)

    J. C. Barrett, C. A. Afshari, L. A. Annab in Journal of Cancer Research and Clinical On… (1991)

  15. No Access

    Article

    Intrafamiliar long-time epidemiology of drug-resistance factors and other plasmids in fecalE. coli

    C. Sutter, G. Lebek in Experientia (1986)