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  1. Article

    Open Access

    Emerging preclinical evidence does not support broad use of hydroxychloroquine in COVID-19 patients

    There is an urgent need for drugs, therapies and vaccines to be available to protect the human population against COVID-19. One of the first approaches taken in the COVID-19 global response was to consider rep...

    S. G. P. Funnell, W. E. Dowling, C. Muñoz-Fontela, P.-S. Gsell… in Nature Communications (2020)

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  2. No Access

    Article

    Conjugation of SUMO to p85 leads to a novel mechanism of PI3K regulation

    Class IA phosphatidylinositol 3-kinases (PI3Ks) are composed of p110 catalytic and p85 regulatory subunits. How regulatory subunits modulate PI3K activity remains only partially understood. Here we identified ...

    C F de la Cruz-Herrera, M Baz-Martínez, V Lang, A El Motiam, J Barbazán… in Oncogene (2016)

  3. No Access

    Article

    Kaposi’s sarcoma-associated herpesvirus lana2 protein interacts with the pocket proteins and inhibits their sumoylation

    The pocket proteins retinoblastoma protein (pRb), p107 and p130 are the key targets of oncoproteins expressed by DNA tumor viruses. Some of these viral proteins contain an LXCXE motif that mediates the interac...

    L Marcos-Villar, P Gallego, C Muñoz-Fontela, C F de la Cruz-Herrera, M Campagna… in Oncogene (2014)