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  1. No Access

    Chapter and Conference Paper

    Molekulargenetische Untersuchungen beim yon Willebrand-Syndrom

    Der von Willebrand-Faktor ist ein multimeres Glykoprotein, welches in der Hämostase zwei wichtige Funktionen erfüllt. Einerseits wird er zur Anlagerung der Plättchen an geschädigtes Endothel benötigt, anderers...

    C. Mannhalter, S. Parzer, P. A. Kyrle in 20. Hämophilie-Symposion Hamburg 1989 (1990)

  2. No Access

    Article

    Detection of engraftment and mixed chimerism following bone marrow transplantation using PCR amplification of a highly variable region-variable number of tandem repeats (VNTR) in the von Willebrand factor gene

    Detection of host cells in peripheral blood and/or bone marrow (mixed chimerism) of patients who have undergone bone marrow transplantation (BMT) is possible using either immunological methods or cytogenetic o...

    A. Gaiger, C. Mannhalter, W. Hinterberger, O. Haas, C. Marosi… in Annals of Hematology (1991)

  3. No Access

    Chapter and Conference Paper

    Faktor XII-Mangel und Thrombophilie

    Die Bedeutung des Faktor XII-Mangels als Risikofaktor für eine erhöhte Thromboseneigung ist bis in die heutige Zeit ungeklärt. Nahezu alle Publikationen, die sich mit Faktor XII (F. XII)-Mangel bzw. F. XII-Man...

    C. Mannhalter, W. M. Halbmayer, M. Fischer in 22. Hämophilie-Symposion Hamburg 1991 (1992)

  4. Article

    Abstract

    Ch. Mache, Ch. Urban, H. Sauer, G. Brandesky, H. Meßner… in Annals of Hematology (1992)

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  5. No Access

    Article

    Genetik und kolorektales Karzinom

    De Anteil der familiär adenomatösen Polyposis coli (FAP) und der Lynch-Syndrome an allen kolorektalen Karzinomen beträgt 10%. Die Kenntnis der klinischen Charakteristika dieser Erkrankungen hat Bedeutung für T...

    Dr. Judith Karner-Hanusch, B. Habler, C. Mannhalter, E. Roth in Acta Chirurgica Austriaca (1992)

  6. No Access

    Article

    Relationship of myc protein expression to the phenotype and to the growth potential of HOC-7 ovarian cancer cells

    In this investigation we demonstrate expression of myc oncoproteins in HOC-7 ovarian adenocarcinoma cells. The cells were exposed to differentiation inducing agents such as dimethyl sulfoxide (DMSO), N,N-dimet...

    C Somay, TW Grunt, C Mannhalter, C Dittrich in British Journal of Cancer (1992)

  7. No Access

    Article

    Adsorption of coagulation factors on to haemodialysis membranes during standard haemodialysis

    One of the initial events upon contact of blood with artificial surfaces is the deposition of a heterogeneous protein layer on the foreign material. Proteins of the blood coagulation system are known to be inv...

    S. Parzer, P. Balcke, C. Mannhalter in Journal of Materials Science: Materials in Medicine (1993)

  8. No Access

    Article

    Kinetics of minimal residual disease during induction/consolidation therapy in standard-risk adult B-lineage acute lymphoblastic leukemia

    We have compared the kinetics of minimal residual disease (MRD) by simultaneous polymerase chain reaction (PCR) monitoring with oligonucleotides for the immunoglobulin heavy chain (IgH) complementarity-determi...

    C. Scholten, M. Födinger, M. Mitterbauer, K. Laczika… in Annals of Hematology (1995)

  9. No Access

    Chapter and Conference Paper

    Molekularbiologie des Protein-C- und Protein-S-Mangels

    Protein C und sein Cofaktor Protein S spielen eine wichtige Rolle im antikoagulatorischen Gerinnungssystem [1, 2]. Protein C, ein Vitamin-K-abhängiges Glykoprotein, wird durch den Thrombin-Thrombomodulin-Kompl...

    C. Mannhalter, S. Mustafa, I. Pabinger in 25. Hämophilie-Symposion Hamburg 1994 (1996)

  10. No Access

    Article

    Long-term leukemia-free survival after allogeneic marrow transplantation in patients with acute myelogenous leukemia

    Between February 1982 and April 1995, 62 patients (37 male, 25 female) with acute myelogenous leukemia (AML) with a median age of 32 years (19–51 years) received allogeneic marrow grafts from an HLA-identical ...

    H. T. Greinix, F. Keil, S. A. Brugger, E. Reiter, W. Linkesch… in Annals of Hematology (1996)

  11. No Access

    Article

    Identification of a variable number tandem repeat region in the human T cell receptor alpha-delta (TCRAD) locus

    A number of different polymorphisms have been observed in coding as well as in non-coding regions of T cell receptor (TCR) genes. We report the identification and characterization of a highly polymorphic locu...

    Heidi Buchmayer, Helmut Rumpold, C. Mannhalter in Human Genetics (1996)

  12. No Access

    Article

    FLAG (fludarabine, cytosine arabinoside, G-CSF) for refractory and relapsed acute myeloid leukemia

     Twenty-two patients with refractory or relapsed AML were treated with FLAG [25 mg/m2 fludarabine daily (days 1–5), 2 g/m2 daily Ara-C (days 1–5) and 400 μg/m2 daily G-CSF (day -1 till the absolute neutrophil cou...

    I.-M. Huhmann, H. H. Watzke, K. Geissler, H. Gisslinger, U. Jäger… in Annals of Hematology (1996)

  13. No Access

    Article

    Prognostic significance of WT1 gene expression at diagnosis in adult de novo acute myeloid leukemia

    We examined the presence of WT1-specific mRNA in bone marrow samples of 125 patients with de novo acute myeloid leukemia at diagnosis by two-step RT-PCR. The sensitivity of the assay was 1:100 (first step) and 1:...

    D Schmid, G Heinze, B Linnerth, K Tisljar, R Kusec, K Geissler, C Sillaber… in Leukemia (1997)

  14. No Access

    Article

    Leukemia-free survival and mortality in patients with refractory or relapsed acute leukemia given marrow transplants from sibling and unrelated donors

    Between April 1982 and February 1997 39 patients (24 male, 15 female) with refractory acute leukemia and a median age of 31 years (19–51 years) received allogeneic marrow grafts from an HLA-identical sibling (n =...

    HT Greinix, E Reiter, F Keil, G Fischer, K Lechner… in Bone Marrow Transplantation (1998)

  15. No Access

    Article

    K-ras mutations as pathogenetic and diagnostic markers in pancreatic cancer

    K-ras codon 12 mutations are an early event in pancreatic carcinogenesis. However more than 1 in 1000 cells have to be mutated and other (additional?) mutations may be necessary for the development of pancreat...

    C. Mannhalter, D. Koizar, A. Chott, G. Mitterbauer, G. Udvardi in Acta chirurgica Austriaca (1998)

  16. No Access

    Article

    Hypofibrinogenemia in non-M3 acute myeloid leukemia. Incidence, clinical and laboratory characteristics and prognosis

    Among 379 patients with AML with FAB type M1, 2 and M4–7 diagnosed between 1978 and 1997 in our institution, 19 (5%) had hypofibrinogenemia (HF), ie a fibrinogen level <180 mg/dl. compared to patients with nor...

    A Weltermann, I Pabinger, K Geissler, U Jäger, H Gisslinger, P Knöbl… in Leukemia (1998)

  17. No Access

    Article

    Graft-versus-host disease following second syngeneic stem cell transplantation for relapsed chronic myeloid leukemia

     Allogeneic bone marrow transplantation is the only curative treatment for patients with Philadelphia chromosome-positive chronic myeloid leukemia (CML); however, recurrence of disease remains a major cause of...

    E. Reiter, H. T. Greinix, G. Mitterbauer, G. Fischer, F. Keil… in Annals of Hematology (1998)

  18. No Access

    Article

    Detection of the WT1 transcript by RT-PCR in complete remission has no prognostic relevance in de novo acute myeloid leukemia

    The WT1 gene is expressed in 73–100% of patients with acute myelogenous leukemia (AML) and is thought to play a role in maintaining the viability of leukemic cells. WT1 has been proposed as a marker for minima...

    A Gaiger, D Schmid, G Heinze, B Linnerth, H Greinix, P Kalhs, K Tisljar… in Leukemia (1998)

  19. No Access

    Chapter

    Faktor XII: Biochemie, Molekularbiologie, Physiologie

    Das menschliche Plasma enthält eine Reihe von Proteinen, die den Körper vor Verletzungen und/ oder dem Eindringen fremder Substanzen schützen. Dabei erfüllen 3 Prozesse, das Blutgerin-nungs- und Fibrinolysesys...

    C. Mannhalter in Hämostaseologie (1999)

  20. No Access

    Chapter

    Faktor XI: Physiologie, Biochemie, Molekularbiologie

    Faktor XI (FXI) wird gemeinsam mit Faktor XII (FXII), Präkallikrein (PK) und hochmolekularem Kininogen (HK) der Gruppe der Kontaktgerinnungsfaktoren zugeordnet. Während es sich bei den ersten 3 Komponenten um ...

    C. Mannhalter in Hämostaseologie (1999)

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