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  1. No Access

    Article

    Systematic analysis of parameters predicting pathological axillary status (ypN0 vs. ypN+) in patients with breast cancer converting from cN+ to ycN0 through primary systemic therapy (PST)

    Optimization of axillary staging among patients converting from clinically node-positive disease to clinically node-negative disease through primary systemic therapy is needed. We aimed at develo** a nomogra...

    C. Liedtke, Hans-Christian Kolberg, L. Kerschke… in Clinical & Experimental Metastasis (2018)

  2. No Access

    Article

    Notch inhibition counteracts Paneth cell death in absence of caspase-8

    Opposing activities of Notch and Wnt signaling regulate mucosal barrier homeostasis and differentiation of intestinal epithelial cells. Specifically, Wnt activity is essential for differentiation of secretory ...

    M. K. Jeon, E. Kaemmerer, U. Schneider, M. Schiffer, C. Klaus… in Virchows Archiv (2018)

  3. Article

    Open Access

    Lack of gp130 expression in hepatocytes attenuates tumor progression in the DEN model

    Chronic liver inflammation is a crucial event in the development and growth of hepatocellular carcinoma (HCC). Compelling evidence has shown that interleukin-6 (IL-6)/gp130-dependent signaling has a fundamenta...

    M Hatting, M Spannbauer, J Peng, M Al Masaoudi, G Sellge… in Cell Death & Disease (2015)

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  4. Article

    Open Access

    Pro-apoptotic Sorafenib signaling in murine hepatocytes depends on malignancy and is associated with PUMA expression in vitro and in vivo

    The multi-kinase inhibitor Sorafenib increases the survival of patients with advanced hepatocellular carcinoma (HCC). Current data suggest that Sorafenib inhibits cellular proliferation and angiogenesis and pr...

    R Sonntag, N Gassler, J-M Bangen, C Trautwein, C Liedtke in Cell Death & Disease (2014)

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  5. Article

    TNFR1 determines progression of chronic liver injury in the IKKγ/Nemo genetic model

    Death receptor-mediated hepatocyte apoptosis is implicated in a wide range of liver diseases including viral and alcoholic hepatitis, ischemia/reperfusion injury, fulminant hepatic failure, cholestatic liver i...

    F J Cubero, A Singh, E Borkham-Kamphorst, Y A Nevzorova… in Cell Death & Differentiation (2013)

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  6. Article

    Open Access

    Predictive value of HER2 serum levels in patients treated with lapatinib or trastuzumab – a translational project in the neoadjuvant GeparQuinto trial

    We were able to demonstrate a predictive value of serum HER2 (sHER2) in patients receiving trastuzumab in the neoadjuvant GeparQuattro trial. However, the role of sHER2 in patients receiving neoadjuvant therap...

    I Witzel, S Loibl, G von Minckwitz, H Eidtmann, T Fehm… in British Journal of Cancer (2012)

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  7. Article

    Open Access

    Squalene epoxidase, located on chromosome 8q24.1, is upregulated in 8q+ breast cancer and indicates poor clinical outcome in stage I and II disease

    Gains of chromosomes 7p and 8q are associated with poor prognosis among oestrogen receptor-positive (ER+) stage I/II breast cancer. To identify transcriptional changes associated with this breast cancer subtyp...

    M W Helms, D Kemming, H Pospisil, U Vogt, H Buerger… in British Journal of Cancer (2008)

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  8. No Access

    Article

    Monoclonal antibody TOP 71 recognizes a tonoplast protein of wide distribution in the plant kingdom

    Highly purified tonoplast and plasma-membrane vesicles isolated from roots of Lepidium sativum L. (garden cress) were used as a starting material for generating a monoclonal antibody against plant tonoplast. Tono...

    C. Liedtke, G. Martiny-Baron, D. Volkmann, G. F. E. Scherer in Planta (1993)