-
Article
Open AccessWidespread detection of highly pathogenic H5 influenza viruses in wild birds from the Pacific Flyway of the United States
A novel highly pathogenic avian influenza virus belonging to the H5 clade 2.3.4.4 variant viruses was detected in North America in late 2014. Motivated by the identification of these viruses in domestic poultr...
-
Article
Microvascular free tissue transfer for gene delivery: in vivo evaluation of different routes of plasmid and adenoviral delivery
Transfer of healthy autologous tissue as a microvascular free flap facilitates reconstruction during ablative cancer surgery. In addition to filling surgical defects, free flaps might concentrate viral vectors...
-
Article
Inflammatory tumour cell killing by oncolytic reovirus for the treatment of melanoma
Reovirus is a promising unmodified double-stranded RNA (dsRNA) anti-cancer oncolytic virus, which is thought to specifically target cells with activated Ras. Although reovirus has been tested in a wide range o...
-
Article
Characterization of the adaptive and innate immune response to intravenous oncolytic reovirus (Dearing type 3) during a phase I clinical trial
There is an emerging realization from animal models that the immune response may have both detrimental and beneficial therapeutic effects during cancer virotherapy. However, there is a dearth of clinical data ...
-
Article
Escherichia coli nitroreductase plus CB1954 enhances the effect of radiotherapy in vitro and in vivo
Escherichia coli nitroreductase (NTR) converts the prodrug CB1954 (5-(aziridin-1-yl)-2,4-dinitrobenzamide) into a bifunctional alkylating agent that causes DNA crosslinks. In this study, the ability of NTR to enh...
-
Article
Reovirus and other oncolytic viruses for the targeted treatment of cancer
In the last 50 years, there have been a number of anecdotal reports of viral infections causing transient cancer remissions in patients with advanced disease. However, during the last decade, these reports hav...
-
Chapter
Nutritional Improvement of Lupin Seed Protein Using Gene Technology
The nutritive value of lupin, an important grain legume for animal production, has been improved by the transformation of a chimeric gene specifying seed-specific expression of a sulfur-rich sunflower seed alb...
-
Article
Effects of Processing on Fiber/Matrix Interfaces in Ni3Al/Sapphire Single Crystal Composites
Composites consisting of Ni3Al modified with Zr, Fe, and B (IC-50) reinforced with continuous sapphire single crystal fibers have been prepared by vacuum hot pressing foil/fiber multilayers. Previous research det...
-
Chapter
The Zinc Requirements of Grazing Ruminants
Zinc (Zn) plays an essential role in animal nutrition as a component of a number of critical enzymes. Animals fed diets containing less than 5 mg Zn/kg develop signs of severe Zn deficiency: loss of appetite, ...
-
Article
Foreword
-
Article
The Effect of Bulk Boron Level on its Segregation to Grain Boundaries in Substoichiometric Ni3Al
It is well established that the grain boundary strength (and thus the ductility) of polycrystalline Ni3Al is a function of the level of boron segregated to su h boundaries. This paper presents some Auger Electron...
-
Article
Evaluation of the effects of segregation on austenite grain boundary energy in Fe-C-X alloys
A scanning Auger microprobe study has been made of the segregation of substitutional alloying elements to austenite grain boundaries in Fe-C-X alloys (where X = Mn, Ni, Si, Co, and Mo). The grain boundary enri...
-
Chapter
A Re-Appraisal of the Recommended Zinc Requirements for Grazing Livestock
According to published estimates of zinc requirements (e.g. ARC 1980), breeding livestock grazing dry autumn pastures in extensive areas of southwestern Australia are grossly zinc deficient. Pasture zinc conce...
-
Article
The Segregation of Boron and Its Effect on the Fracture of An Ni3Si Based Alloy
It is now well established that microalloying additions of B to Ni3Al drastically reduce low temperature grain boundary fracture and consequently increase the ductility of this intermetallic compound. One possibl...
-
Article
On the improvement of creep strength and ductility of Ni-20 pct Cr by small zirconium additions
The creep and fracture properties of high-purity Ni-20 pct Cr and Ni-20 pct Cr-0.11 pct Zr alloys are compared at 1073 K in vacuum. The Ni-20 pct Cr alloy cavitates at the grain boundaries and fractures interg...
-
Article
Weldability of Ni3Al-Type Aluminide Alloys
If the ductile Ni3Al-based aluminides are to achieve their full potential as engineering materials, they must demonstrate a capability for being joined by conventional welding processes. The goal of this study wa...
-
Article
Design of Ductile Polycrystalline Ni3Al Alloys
This paper provides a comprehensive review of current efforts on design of ductile polycrystalline Ni3Al alloys. Microalloying has proven to be very effective in alleviating the grain-boundary emibrittlement prob...
-
Article
The Role of Trace Elements and Interfaces in Creep Failure
-
Article
High temperature embrittlement of NI and Ni-Cr alloys by trace elements
The effects of Sb, Sn, and Zr additions on the creep properties of Ni and Ni + 20 pct Cr are reported. Antimony and tin additions (~1 wt pct) induce extensive grain boundary cavitation in nickel, while smaller...
-
Chapter and Conference Paper
Early/Late Component Ratio in Pattern-Reversal VEP: Normative Data and Clinical Applications
It has been well-established that there is a quite reliable implicit time to a positive component (ca 100 msec) in respect to pattern reversal. This has been used as a neurological test of the integrity of the...
