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Article
Lipid Peroxidation of Lung Surfactant in Experimental Neonatal Group B Streptococcal Pneumonia
Group B streptococcal (GBS) pneumonia, with neutrophilic granulocytes immigrating into the lungs, may occur in neonates. The incidence is particularly high among preterm infants, who often are treated with exo...
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Article
Direct and Phagocyte-mediated Lipid Peroxidation of Lung Surfactant by Group B Streptococci
In newborn infants, group B streptococci (GBS) often cause pneumonia, with polymorphonuclear leukocytes (PMN) migrating into the lungs. Because surfactant therapy may be needed in such patients, we evaluated ...
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Article
Lipid Peroxidation of Lung Surfactant by Bacteria
The epithelium of the lung is lined with extracellular pulmonary surfactant. This is the surface that invading bacteria first come into contact with when they enter the alveoli. As bacteria become established...
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Article
Fungal prophylaxis by reduction of fungal colonization by oral administration of bovine anti-Candida antibodies in bone marrow transplant recipients
Candida overgrowth and invasion constitute a serious threat with a high mortality in BMT recipients. Currently available topical antifungal prophylaxis is largely ineffective, and as resistance to existing, ab...
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Article
in Vitro Effect of Lung Surfactant on Alveolar Macrophage Defence Mechanisms Against Cryptococcus Neoformans
The effects of a modified natural porcine surfactant (Curosurf) on phagocytosis and killing of Cryptococcus neoformans by alveolar macrophages and on the production of superoxide anions were investigated in vi...
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Article
Lung Function and Bacterial Proliferation in Experimental Neonatal Pneumonia in Ventilated Rabbits Exposed to Monoclonal Antibody to Surfactant Protein A
Surfactant protein A (SP-A) increases the resistance of surfactant to inhibition by plasma and other proteins. In a previous study we found that a monoclonal anti-SP-A antibody (R 5) increased the sensitivity...
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Article
In vivo interaction between alveolar macrophages and Cryptococcus neoformans
In vivo interactions of rabbit alveolar macrophages (AM) and Cryptococcus neoformans, a yeast pathogenic for humans, were studied. As a control, inert silica particles of a similar diameter (5–6 µm) were used....
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Article
Einfluß von Surfactant auf das pulmonale Entzündungsgeschehen und die Elastasefreisetzung bei experimenteller neonataler B-Streptokokken-Pneumonie
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Article
Anticryptococcal activity by alveolar macrophages from rats treated with cortisone acetate during different periods of time
The effect of cortisone acetate (CA) treatment on the anticryptococcal activity by rat alveolar macrophages (AM) was investigated. The animals received a weekly dose of 5 mg CA during 1, 2, 3 or 4 weeks. Follo...
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Article
Effect of N-acetylcysteine(NAC) treatment on HIV-1 infection: a double-blind placebo-controlled trial
Objective: In a double-blind placebo-controlled trial, human immunodeficiency virus (HIV)-seropositive patients with a CD4 lymphocyte cell count of more than 200 × 106⋅l−1 were randomise...