-
Article
Improving outcomes after allogeneic hematopoietic cell transplantation for Hodgkin lymphoma in the brentuximab vedotin era
Allogeneic hematopoietic cell transplantation (alloHCT) remains a valuable treatment alternative for relapsed/refractory (R/R) Hodgkin lymphoma (HL). Data on alloHCT outcomes in the era of new HL therapies are...
-
Article
BEAM conditioning is well-tolerated and yields similar survival in obese and non-obese patients with lymphoma: no requirement for weight-based dose modifications
-
Article
CD56dimCD57+NKG2C+ NK cell expansion is associated with reduced leukemia relapse after reduced intensity HCT
We have recently described a specialized subset of human natural killer (NK) cells with a CD56dimCD57+NKG2C+ phenotype that expand specifically in response to cytomegalovirus (CMV) reactivation in hematopoietic c...
-
Article
The effect of equine antithymocyte globulin on the outcomes of reduced intensity conditioning for AML
Whether or not the benefits of antithymocyte globulin (ATG) on engraftment and GVHD are offset by increased risk of relapse, delayed T-cell recovery and increased infections remains controversial. We retrospec...
-
Article
Higher therapeutic CsA levels early post transplantation reduce risk of acute GVHD and improves survival
We studied whether early CsA trough levels were associated with the risk of acute GVHD in 337 patients after either sibling PBSC or double umbilical cord blood transplantation. All patients, regardless of dono...
-
Article
CXCR4 expression in CD34+ cells and unit predominance after double umbilical cord blood transplantation
-
Article
Factors predicting single-unit predominance after double umbilical cord blood transplantation
Double umbilical cord blood transplantation (dUCBT), developed as a strategy to treat large number of patients with hematologic malignancies, frequently leads to the long-term establishment of a new hematopoie...
-
Article
Reduced-intensity hematopoietic cell transplantation in older patients with AML/MDS: umbilical cord blood is a feasible option for patients without HLA-matched sibling donors
Umbilical cord blood (UCB) has increased access to hematopoietic cell transplantation (HCT) for patients without HLA-matched sibling donors (MSD). We compared outcomes of HCT using MSD (N=38) or UCB (N=60) among ...
-
Article
Delayed platelet recovery after allogeneic transplantation: a predictor of increased treatment-related mortality and poorer survival
Delayed platelet recovery (DPR) is common after allo-SCT. Insufficient data on risk factors and association with OS and TRM are available. We conducted a retrospective analysis of all allografts at the Univers...
-
Article
High fludarabine exposure and relationship with treatment-related mortality after nonmyeloablative hematopoietic cell transplantation
Despite its common use in nonmyeloablative preparative regimens, the pharmacokinetics of fludarabine are poorly characterized in hematopoietic cell transplantation (HCT) recipients and exposure-response relati...
-
Article
Going straight to the point: intra-BM injection of hematopoietic progenitors
Intra-BM injection (IBMI) has been used clinically as a technique to deliver medications, blood products and fluids to critically ill children and war-wounded soldiers. Interest in IBMI has now been renewed in...
-
Article
A modified comorbidity index for hematopoietic cell transplantation
A recent validation analysis at our center among allogeneic hematopoietic cell transplant (HCT) recipients did not find the HCT-specific comorbidity index (HCT-CI) to clearly segregate patient's transplant-rel...
-
Article
Herpes simplex virus encephalitis after allogeneic transplantation: an instructive case
-
Article
Future of cord blood for oncology uses
The utilization of umbilical cord blood (UCB) as a source of stem cells for transplantation has grown substantially in the last decade. Already an established practice for the treatment of children with hemato...
-
Article
Intra-BM injection to enhance engraftment after myeloablative umbilical cord blood transplantation with two partially HLA-matched units
The time to neutrophil engraftment for adult patients after myeloablative double unit umbilical cord blood (UCB) transplantation is 23 days when the two units are given i.v. We hypothesized that the intra-BM i...
-
Article
Fewer infections and lower infection-related mortality following non-myeloablative versus myeloablative conditioning for allotransplantation of patients with lymphoma
Non-myeloablative (NMA) allogeneic donor SCT for patients with relapsed lymphoma is associated with lower treatment-related mortality (TRM). However, the impact of conditioning intensity on post transplant inf...
