-
Article
Repeated-dose toxicity and toxicokinetic study of isobutylparaben in rats subcutaneously treated for 13 weeks
Parabens have historically served as antimicrobial preservatives in a range of consumables such as food, beverages, medications, and personal care products due to their broad-spectrum antibacterial and antifun...
-
Article
Correction to: Thirteen-week subcutaneous repeated dose toxicity study of butylparaben and its toxicokinetics in rats
A correction to this paper has been published: https://doi.org/10.1007/s00204-021-03054-8
-
Article
Thirteen-week subcutaneous repeated dose toxicity study of butylparaben and its toxicokinetics in rats
Parabens are widely used preservatives in cosmetics and pharmaceutical products and are approved as food additives. These chemicals have been considered safe for many years. However, the literature classifies ...
-
Article
Open AccessAnti-diabetic activity of field cricket glycosaminoglycan by ameliorating oxidative stress
Field cricket (Gryllus bimaculatus) is newly emerged as an edible insect in several countries. Anti-inflammatory effect of glycosaminoglycan derived from this cricket on chronic disease animal model such as diabe...
-
Article
Adverse health risk from prolonged consumption of formaldehyde-preserved carps in eastern region of Indian population
Presence of formaldehyde as a preservative in commonly available fishes (Labeo rohita, Catla catla, Anabas testudineus and Clarias gariepinus) has become a serious health concern in the public health of eastern r...
-
Article
Integration of transcriptomics, proteomics and metabolomics identifies biomarkers for pulmonary injury by polyhexamethylene guanidine phosphate (PHMG-p), a humidifier disinfectant, in rats
Polyhexamethylene guanidine phosphate (PHMG-p) was used as a humidifier disinfectant in Korea. PHMG induced severe pulmonary fibrosis in Koreans. The objective of this study was to elucidate mechanism of pulmo...
-
Article
Open AccessRisk Assessment of Ethylhexyl Dimethyl PABA in Cosmetics
Ethylhexyl dimethyl para-aminobenzoic acid (PABA) is an oily yellow liquid derivative of water-soluble PABA commonly used in sunscreen. Ethylhexyl dimethyl PABA is widely used as an ingredient in many cosmetic...
-
Article
Open AccessRisk Assessment of 5-Chloro-2-Methylisothiazol-3(2H)-One/2-Methylisothiazol-3(2H)-One (CMIT/MIT) Used as a Preservative in Cosmetics
The mixture of 5-chloro-2-methylisothiazol-3(2H)-one (CMIT) and 2-methylisothiazol-3(2H)-one (MIT), CMIT/MIT, is a preservative in cosmetics. CMIT/MIT is a highly effective preservative; however, it is also a ...
-
Article
Open AccessRisk Assessment of Drometrizole, a Cosmetic Ingredient used as an Ultraviolet Light Absorber
As the use of cosmetics has greatly increased in a daily life, safety issues with cosmetic ingredients have drawn an attention. Drometrizole [2-(2′-hydroxy-5′-methylphenyl)benzotriazole] is categorized as a su...
-
Article
Open AccessRisk Assessment of Triclosan, a Cosmetic Preservative
Triclosan (TCS) is an antimicrobial compound used in consumer products. The purpose of current study was to examine toxicology and risk assessment of TCS based on available data. Acute toxicities of oral, tran...
-
Article
Open AccessThe general Assembly of the International Association of Environmental Mutagenesis and Genomics Societies (IAEMGS) in 2017
The International Association of Environmental Mutagenesis and Genomics Societies (IAEMGS) is a global organization that promotes applied and basic research on environmental mutagenesis and genomics. IAEMGS is...
-
Article
Selenium-binding protein 1: a sensitive urinary biomarker to detect heavy metal-induced nephrotoxicity
Identifying novel biomarkers to detect nephrotoxicity is clinically important. Here, we attempted to identify new biomarkers for mercury-induced nephrotoxicity and compared their sensitivity to that of traditi...
-
Article
Genetic and epigenetic cancer chemoprevention on molecular targets during multistage carcinogenesis
The main goal of cancer chemoprevention is to prevent or halt the progression of carcinogenesis with the administration of synthetic or natural compounds. Fundamental chemopreventive strategies include inhibit...
-
Article
Open AccessPyruvate Kinase M2: A Novel Biomarker for the Early Detection of Acute Kidney Injury
The identification of biomarkers for the early detection of acute kidney injury (AKI) is clinically important. Acute kidney injury (AKI) in critically ill patients is closely associated with increased morbidit...
-
Article
Open AccessEvaluation of Renal Toxicity by Combination Exposure to Melamine and Cyanuric Acid in Male Sprague-Dawley Rats
Melamine-induced nephrotoxicity is closely associated with crystal formation in the kidney caused by combined exposure to melamine (Mel) and cyanuric acid (CA). However, there are few dosage-finding studies fo...
-
Article
Evaluation of metabolomic profiling against renal toxicity in Sprague–Dawley rats treated with melamine and cyanuric acid
Melamine-induced renal toxicity is associated with crystal formation in the kidney following exposure to melamine and cyanuric acid. However, metabolomic profiling of intact kidney tissue after chronic intake ...
-
Article
Open AccessToxicological Characterization of Phthalic Acid
There has been growing concern about the toxicity of phthalate esters. Phthalate esters are being used widely for the production of perfume, nail varnish, hairsprays and other personal/cosmetic uses. Recently,...
-
Article
Open AccessMolecular Mechanism of Tetrabromobisphenol A (TBBPA)-induced Target Organ Toxicity in Sprague-Dawley Male Rats
Brominated flame retardants (BFRs) are present in many consumer products ranging from fabrics to plastics and electronics. Wide use of flame retardants can pose an environmental hazard, which makes it importan...
-
Article
Open AccessComparison of the Short Term Toxicity of Phthalate Diesters and Monoesters in Sprague-Dawley Male Rats
This study was carried out to investigate the short term toxicity of nine phthalate diesters including di-2(ethylhexyl) phthalate (DEHP), di(n-butyl) phthalate (DBP), di-n-octyl phthalate (DnOP), diethyl phtha...
-
Article
Open AccessSubacute Oral Toxicity Study of a New Type of Cordyceps, Paecilomyces sinclairii, in Sprague-Dawley Rats
This study was conducted to investigate the 2 week-oral toxicity of Paecilomyces sinclairii in Sprague-Dawley rats. P. sinclairii was daily administered to male and female rats for 2 weeks with different dose lev...
