7 Result(s)
within
Byung-Cheon Jeong
English
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Article
Structural basis for the recognition of N-end rule substrates by the UBR box of ubiquitin ligases
In the N-end rule pathway, the N-terminal residue of a protein is recognized by specific E3 ligases that promote its ubiquitination and proteasomal degradation. Now the structural basis for the recognition of ...
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Article
MG53-induced IRS-1 ubiquitination negatively regulates skeletal myogenesis and insulin signalling
Mitsugumin 53 (MG53) negatively regulates skeletal myogenesis by targeting insulin receptor substrate 1 (IRS-1). Here, we show that MG53 is an ubiquitin E3 ligase that induces IRS-1 ubiquitination with the hel...
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Article
Open AccessHeme enables proper positioning of Drosha and DGCR8 on primary microRNAs
MicroRNAs regulate the expression of many proteins and require specific maturation steps. Primary microRNA transcripts (pri-miRs) are cleaved by Microprocessor, a complex containing the RNase Drosha and its pa...
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Article
Open AccessMechanistic insight into TRIP13-catalyzed Mad2 structural transition and spindle checkpoint silencing
The spindle checkpoint maintains genomic stability and prevents aneuploidy. Unattached kinetochores convert the latent open conformer of the checkpoint protein Mad2 (O-Mad2) to the active closed conformer (C-M...
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Article
Open AccessPublisher Correction: Heme enables proper positioning of Drosha and DGCR8 on primary microRNAs
The original version of this Article contained an error in Fig. 1. In panel d, the model on the right of the panel was incorrectly labeled ‘+Heme’, and should have read ‘− Heme’. This has now been corrected in...
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Article
Cryo-EM structure of the Hippo signaling integrator human STRIPAK
The striatin-interacting phosphatase and kinase (STRIPAK) complex is a large, multisubunit protein phosphatase 2A (PP2A) assembly that integrates diverse cellular signals in the Hippo pathway to regulate cell ...
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Article
Open AccessStructure and activation of the RING E3 ubiquitin ligase TRIM72 on the membrane
Defects in plasma membrane repair can lead to muscle and heart diseases in humans. Tripartite motif-containing protein (TRIM)72 (mitsugumin 53; MG53) has been determined to rapidly nucleate vesicles at the sit...
