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Article
Open AccessPublisher Correction: Heme enables proper positioning of Drosha and DGCR8 on primary microRNAs
The original version of this Article contained an error in Fig. 1. In panel d, the model on the right of the panel was incorrectly labeled ‘+Heme’, and should have read ‘− Heme’. This has now been corrected in...
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Article
Open AccessMechanistic insight into TRIP13-catalyzed Mad2 structural transition and spindle checkpoint silencing
The spindle checkpoint maintains genomic stability and prevents aneuploidy. Unattached kinetochores convert the latent open conformer of the checkpoint protein Mad2 (O-Mad2) to the active closed conformer (C-M...
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Article
Open AccessHeme enables proper positioning of Drosha and DGCR8 on primary microRNAs
MicroRNAs regulate the expression of many proteins and require specific maturation steps. Primary microRNA transcripts (pri-miRs) are cleaved by Microprocessor, a complex containing the RNase Drosha and its pa...
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Article
MG53-induced IRS-1 ubiquitination negatively regulates skeletal myogenesis and insulin signalling
Mitsugumin 53 (MG53) negatively regulates skeletal myogenesis by targeting insulin receptor substrate 1 (IRS-1). Here, we show that MG53 is an ubiquitin E3 ligase that induces IRS-1 ubiquitination with the hel...