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  1. No Access

    Article

    Circulating Extracellular Proteasome in the Cerebrospinal Fluid: A Study on Concentration and Proteolytic Activity

    Alterations of the intracellular ubiquitin–proteasome pathway are found in neurodegenerative and inflammatory disorders of the central nervous system, as well as in its malignancies. Inhibitory substrates of t...

    Oliver Mueller, Timur Anlasik, Jonas Wiedemann… in Journal of Molecular Neuroscience (2012)

  2. No Access

    Article

    Reciprocal Effects of α-Synuclein Overexpression and Proteasome Inhibition in Neuronal Cells and Tissue

    Defects in the 20S/26S proteasome and conformational changes in α-synuclein (α-syn) are implicated in the development of sporadic and familial cases of PD. The objective of this study was to evaluate whether α...

    Melanie Dyllick-Brenzinger, Cheryl A. D’Souza, Burkhardt Dahlmann… in Neurotoxicity Research (2010)