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Dose-finding study of hepatic arterial infusion of irinotecan-based treatment in patients with advanced cancers metastatic to the liver

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  1. Article

    Open Access

    A phase I trial of the pan-ERBB inhibitor neratinib combined with the MEK inhibitor trametinib in patients with advanced cancer with EGFR mutation/amplification, HER2 mutation/amplification, HER3/4 mutation or KRAS mutation

    Aberrant alterations of ERBB receptor tyrosine kinases lead to tumorigenesis. Single agent therapy targeting EGFR or HER2 has shown clinical successes, but drug resistance often develops due to aberrant or co...

    Sarina A. Piha-Paul, Chieh Tseng, Hai T. Tran… in Cancer Chemotherapy and Pharmacology (2023)

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  2. Article

    Open Access

    Signet ring cell colorectal cancer: genomic insights into a rare subpopulation of colorectal adenocarcinoma

    Signet ring cell carcinoma (SRCC) is a rare subtype of colorectal cancer (CRC). The aim of this study was to characterise the genomic alterations and outcomes of SRCC.

    Krittiya Korphaisarn, Van Morris, Jenifer S. Davis… in British Journal of Cancer (2019)

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