Skip to main content

5 Result(s)

within Bryan G. Hughes Remove this filter

and

  1. Article

    Open Access

    Estimating the occurrence of primary ubiquinone deficiency by analysis of large-scale sequencing data

    Primary ubiquinone (UQ) deficiency is an important subset of mitochondrial disease that is caused by mutations in UQ biosynthesis genes. To guide therapeutic efforts we sought to estimate the number of individ...

    Bryan G. Hughes, Paul M. Harrison, Siegfried Hekimi in Scientific Reports (2017)

    Download PDF (1541 KB) View Article

  2. No Access

    Article

    Many possible maximum lifespan trajectories

    Bryan G. Hughes, Siegfried Hekimi in Nature (2017)

  3. No Access

    Article

    Targeting MMP-2 to treat ischemic heart injury

    Matrix metalloproteinase (MMPs) are long understood to be involved in remodeling of the extracellular matrix. However, over the past decade, it has become clear that one of the most ubiquitous MMPs, MMP-2, has...

    Bryan G. Hughes, Richard Schulz in Basic Research in Cardiology (2014)

  4. No Access

    Chapter

    Intracellular Matrix Remodeling and Cardiac Function in Ischemia–Reperfusion Injury

    The effects of ischemia on animal and human myocardium have been extensively studied during the last four decades. Myocardial ischemia followed by subsequent reperfusion can cause profound damage to cardiac my...

    **aohu Fan, Mohammad A. M. Ali, Bryan G. Hughes… in Cardiac Remodeling (2013)

  5. Article

    Open Access

    Mclk1+/- mice are not resistant to the development of atherosclerosis

    Mice with a single copy of Mclk1 (a.k.a. Coq7), a gene that encodes a mitochondrial enzyme required for the biosynthesis of ubiquinone and other functions, live longer than wild-type mice. The prolonged survival ...

    Bryan G Hughes, Siegfried Hekimi in Lipids in Health and Disease (2009)

    Download PDF (856 KB) View Article