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  1. No Access

    Protocol

    Generation of Single-Domain Antibody-Based Recombinant Immunotoxins

    The discovery of single-domain antibodies has opened new avenues for drug development. Single-domain antibodies, also known as nanobodies, can access buried epitopes that are inaccessible to conventional antib...

    Bryan D. Fleming, Mitchell Ho in Single-Domain Antibodies (2022)

  2. Article

    Open Access

    Upregulated IL-1β in dysferlin-deficient muscle attenuates regeneration by blunting the response to pro-inflammatory macrophages

    Loss-of-function mutations in the dysferlin gene (DYSF) result in a family of muscle disorders known collectively as the dysferlinopathies. Dysferlin-deficient muscle is characterized by inflammatory foci and ...

    Tatiana V. Cohen, Gina M. Many, Bryan D. Fleming, Viola F. Gnocchi… in Skeletal Muscle (2015)

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