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Article
Open AccessReproducible biomedical benchmarking in the cloud: lessons from crowd-sourced data challenges
Challenges are achieving broad acceptance for addressing many biomedical questions and enabling tool assessment. But ensuring that the methods evaluated are reproducible and reusable is complicated by the dive...
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Article
Open AccessStratification of amyotrophic lateral sclerosis patients: a crowdsourcing approach
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease where substantial heterogeneity in clinical presentation urgently requires a better stratification of patients for the development of dr...
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Article
Open AccessErratum: Crowdsourced assessment of common genetic contribution to predicting anti-TNF treatment response in rheumatoid arthritis
Nature Communications 7: Article number: 12460 (2016); Published: 23 August 2016; Updated: 10 October 2016. The HTML version of this Article incorrectly duplicated the authors S. Louis Bridges, Lindsey Criswel...
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Article
Open AccessCrowdsourced assessment of common genetic contribution to predicting anti-TNF treatment response in rheumatoid arthritis
Rheumatoid arthritis (RA) affects millions world-wide. While anti-TNF treatment is widely used to reduce disease progression, treatment fails in ∼one-third of patients. No biomarker currently exists that ident...
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Article
Open AccessHow dietary arachidonic- and docosahexaenoic- acid rich oils differentially affect the murine hepatic transcriptome
Herein, we expand our previous work on the effects of long chain polyunsaturated fatty acids (LC-PUFA) on the murine hepatic transcriptome using novel statistical and bioinformatic approaches for evaluating mi...
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Article
A model of duration in normal and perturbed reaching movement
In modeling human and primate motor behavior, optimization has been used to mathematically describe hand trajectories during reaching movement, with the duration of the movement given as part of the boundary c...
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Chapter
Using Optimal Control to Model Trajectory Formation and Perturbation Response in a Prehension Task
Our goal is to create a principled account of a body of behavioral kinematic data on reaching and gras**. We show how to transform an optimality principle for overall hand transport into a feedback control ...
