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  1. Article

    Open Access

    Impact of depth of response on survival in patients treated with cobimetinib ± vemurafenib: pooled analysis of BRIM-2, BRIM-3, BRIM-7 and coBRIM

    This pooled analysis investigated the prognostic value of depth of response in two cohorts of patients with BRAFV600-mutated metastatic melanoma treated with vemurafenib or cobimetinib plus vemurafenib.

    Karl D. Lewis, James Larkin, Antoni Ribas, Keith T. Flaherty… in British Journal of Cancer (2019)

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  2. Article

    Open Access

    Health-related quality of life impact of cobimetinib in combination with vemurafenib in patients with advanced or metastatic BRAFV600 mutation–positive melanoma

    In the coBRIM study, cobimetinib plus vemurafenib (C+V) significantly improved survival outcomes vs placebo and vemurafenib (P+V) in patients with advanced/metastatic BRAFV600-mutated melanoma. An analysis of hea...

    Brigitte Dréno, Paolo A Ascierto, Victoria Atkinson… in British Journal of Cancer (2018)

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