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    Article

    Meningioma DNA methylation groups identify biological drivers and therapeutic vulnerabilities

    Meningiomas are the most common primary intracranial tumors. There are no effective medical therapies for meningioma patients, and new treatments have been encumbered by limited understanding of meningioma bio...

    Abrar Choudhury, Stephen T. Magill, Charlotte D. Eaton, Briana C. Prager… in Nature Genetics (2022)

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    Article

    Targeting glioma stem cells through combined BMI1 and EZH2 inhibition

    Microenvironmental pressures in glioblastoma select for glioma stem cells (GSCs) subpopulations that are maintained through preferential activation of BMI1 and EZH2 in different niches. Given the high degree o...

    Xun **, Leo J Y Kim, Qiulian Wu, Lisa C Wallace, Briana C Prager… in Nature Medicine (2017)