Skip to main content

8 Result(s)

within Briana C. Prager Remove this filter

and

  1. Article

    Open Access

    Gα12 signaling regulates transcriptional and phenotypic responses that promote glioblastoma tumor invasion

    In silico interrogation of glioblastoma (GBM) in The Cancer Genome Atlas (TCGA) revealed upregulation of GNA12 (Gα12), encoding the alpha subunit of the heterotrimeric G-protein G12, concomitant with overexpressi...

    Olga Meiri Chaim, Shunichiro Miki, Briana C. Prager, Jianhui Ma… in Scientific Reports (2023)

    Download PDF (9026 KB) View Article

  2. Article

    Open Access

    LncRNA INHEG promotes glioma stem cell maintenance and tumorigenicity through regulating rRNA 2’-O-methylation

    Glioblastoma (GBM) ranks among the most lethal of human cancers, containing glioma stem cells (GSCs) that display therapeutic resistance. Here, we report that the lncRNA INHEG is highly expressed in GSCs compa...

    Lihui Liu, Ziyang Liu, Qinghua Liu, Wei Wu, Peng Lin, **ng Liu… in Nature Communications (2023)

    Download PDF (4432 KB) View Article

  3. No Access

    Article

    Meningioma DNA methylation groups identify biological drivers and therapeutic vulnerabilities

    Meningiomas are the most common primary intracranial tumors. There are no effective medical therapies for meningioma patients, and new treatments have been encumbered by limited understanding of meningioma bio...

    Abrar Choudhury, Stephen T. Magill, Charlotte D. Eaton, Briana C. Prager… in Nature Genetics (2022)

  4. Article

    Open Access

    CHMP2A regulates tumor sensitivity to natural killer cell-mediated cytotoxicity

    Natural killer (NK) cells are known to mediate killing of various cancer types, but tumor cells can develop resistance mechanisms to escape NK cell-mediated killing. Here, we use a “two cell type” whole genome...

    Davide Bernareggi, Qi **e, Briana C. Prager, Jiyoung Yun… in Nature Communications (2022)

    Download PDF (2242 KB) View Article

  5. No Access

    Article

    Three-dimensional bioprinted glioblastoma microenvironments model cellular dependencies and immune interactions

    Brain tumors are dynamic complex ecosystems with multiple cell types. To model the brain tumor microenvironment in a reproducible and scalable system, we developed a rapid three-dimensional (3D) bioprinting me...

    Min Tang, Qi **e, Ryan C. Gimple, Zheng Zhong, Trevor Tam, **g Tian… in Cell Research (2020)

  6. No Access

    Article

    Therapeutic targeting of ependymoma as informed by oncogenic enhancer profiling

    Super enhancers regulate oncogenes and other molecular targets in ependymomas, and identification of these genes provides potential therapeutic targets.

    Stephen C. Mack, Kristian W. Pajtler, Lukas Chavez, Konstantin Okonechnikov… in Nature (2018)

  7. No Access

    Article

    Targeting glioma stem cells through combined BMI1 and EZH2 inhibition

    Microenvironmental pressures in glioblastoma select for glioma stem cells (GSCs) subpopulations that are maintained through preferential activation of BMI1 and EZH2 in different niches. Given the high degree o...

    Xun **, Leo J Y Kim, Qiulian Wu, Lisa C Wallace, Briana C Prager… in Nature Medicine (2017)

  8. No Access

    Article

    Purine synthesis promotes maintenance of brain tumor initiating cells in glioma

    Brain tumor initiating cells (BTICs) utilize high-affinity glucose uptake, which is normally active in neurons to maintain energy demands and self-renew. Leveraging metabolomic and genomic analyses, Wang et al. r...

    **uxing Wang, Kailin Yang, Qi **e, Qiulian Wu, Stephen C Mack… in Nature Neuroscience (2017)