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Article
Airway hillocks are injury-resistant reservoirs of unique plastic stem cells
Airway hillocks are stratified epithelial structures of unknown function1. Hillocks persist for months and have a unique population of basal stem cells that express genes associated with barrier function and cell...
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Article
Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics
Angiotensin-converting enzyme 2 (ACE2) and accessory proteases (TMPRSS2 and CTSL) are needed for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cellular entry, and their expression may shed light...
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Article
Open AccessA Group of Olfactory Receptor Alleles that Encode Full Length Proteins are Down-Regulated as Olfactory Sensory Neurons Mature
The family of olfactory receptors (ORs) subserves the sense of smell and includes both functional alleles and pseudogenes, the latter identified by mutations resulting in frame shift or premature truncation. D...
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Article
Open AccessEffects of codon optimization on coagulation factor IX translation and structure: Implications for protein and gene therapies
Synonymous codons occur with different frequencies in different organisms, a phenomenon termed codon usage bias. Codon optimization, a common term for a variety of approaches used widely by the biopharmaceutic...
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Article
A revised airway epithelial hierarchy includes CFTR-expressing ionocytes
The airways of the lung are the primary sites of disease in asthma and cystic fibrosis. Here we study the cellular composition and hierarchy of the mouse tracheal epithelium by single-cell RNA-sequencing (scRN...
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Article
Smart access to 3D structures
QR Chem is a free resource that enables teachers and researchers to link audiences directly to three-dimensional renderings of molecules.
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Article
The most frequent interfaces in olivine aggregates: the GBCD and its importance for grain boundary related processes
Rocks consist of crystal grains separated by grain boundaries that impact the bulk rock properties. Recent studies on metals and ceramics showed that the grain boundary plane orientation is more significant fo...
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Article
Open AccessTGF-β1 conjugated chitosan collagen hydrogels induce chondrogenic differentiation of human synovium-derived stem cells
Unlike bone tissue, articular cartilage regeneration has not been very successful and has many challenges ahead. We have previously developed injectable hydrogels using photopolymerizable chitosan (MeGC) that ...
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Article
Less-Established Risk Factors Are Common in Asian Americans with Hepatitis C Virus: A Case–Controlled Study
The Centers for Disease Control and Prevention recommend screening for hepatitis C virus (HCV) in patients with injection drug use, blood transfusion before 1992, stigmata of liver disease, or born between 194...
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Article
Tuning Colors of Silver Nanoparticle Sheets by Multilayered Crystalline Structures on Metal Substrates
We report a new concept of tuning plasmonic colors of two-dimensional crystalline silver nanoparticle sheets with layer-by-layer structures. The multilayered crystalline sheets fabricated by the Langmuir–Schae...
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Article
Self-assembled Materials Containing Complementary Nucleobase Molecular Recognition
Here we report the nucleic acid/cationic amphiphile based-materials in which we exchange the counter-ions of the polyanionic backbone of the nucleic acids with the cationic amphiphiles to form self-assembled t...
