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  1. Article

    Open Access

    Pharmacokinetics, radiation dosimetry, acute toxicity and automated synthesis of [18F]AmBF3-TATE

    [18F]AmBF3-TATE is a somatostatin agonist that selectively binds to somatostatin receptor subtype 2 (SSTR2). For clinical translation, pharmacokinetics, radiation dosimetry, and acute toxicity of [18F]AmBF3-TATE ...

    Joseph Lau, **he Pan, Etienne Rousseau, Carlos F. Uribe… in EJNMMI Research (2020)

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  2. Article

    Open Access

    The involvement of insulin-like growth factor 2 binding protein 3 (IMP3) in pancreatic cancer cell migration, invasion, and adhesion

    Over-expression of insulin-like growth factor 2 mRNA binding protein 3 (IMP3) is correlated with poor prognosis in pancreatic ductal adenocarcinoma (PDAC). Previous studies examining other cancer types have im...

    Clarissa C Pasiliao, Che-Wei A Chang, Brent W Sutherland, Shannon M Valdez… in BMC Cancer (2015)

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  3. Article

    Open Access

    Irinophore C™, a lipid nanoparticle formulation of irinotecan, abrogates the gastrointestinal effects of irinotecan in a rat model of clinical toxicities

    Irinotecan is a water-soluble camptothecin derivative with clinical activity against colorectal and small cell lung cancers and is currently a standard of care therapeutic in the treatment of colorectal cancer...

    Dawn N. Waterhouse, Brent W. Sutherland, Nancy Dos Santos… in Investigational New Drugs (2014)

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  4. No Access

    Article

    Comparison of bifunctional chelates for 64Cu antibody imaging

    Improved bifunctional chelates (BFCs) are needed to facilitate efficient 64Cu radiolabeling of monoclonal antibodies (mAbs) under mild conditions and to yield stable, target-specific agents. The utility of two no...

    Cara L. Ferreira, Donald T. T. Yapp… in European Journal of Nuclear Medicine and M… (2010)

  5. Article

    Open Access

    QLT0267, a small molecule inhibitor targeting integrin-linked kinase (ILK), and docetaxel can combine to produce synergistic interactions linked to enhanced cytotoxicity, reductions in P-AKT levels, altered F-actin architecture and improved treatment outcomes in an orthotopic breast cancer model

    Substantial preclinical evidence has indicated that inhibition of integrin linked-kinase (ILK) correlates with cytotoxic/cytostatic cellular effects, delayed tumor growth in animal models of cancer, and inhibi...

    Jessica Kalra, Corinna Warburton, Karen Fang, Lincoln Edwards… in Breast Cancer Research (2009)

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  6. No Access

    Article

    Akt phosphorylates the Y-box binding protein 1 at Ser102 located in the cold shock domain and affects the anchorage-independent growth of breast cancer cells

    Akt/PKB is a serine/threonine kinase that promotes tumor cell growth by phosphorylating transcription factors and cell cycle proteins. There is particular interest in finding tumor-specific substrates for Akt ...

    Brent W Sutherland, Jill Kucab, Joyce Wu, Cathy Lee, Maggie C U Cheang… in Oncogene (2005)