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  1. Article

    Open Access

    The involvement of insulin-like growth factor 2 binding protein 3 (IMP3) in pancreatic cancer cell migration, invasion, and adhesion

    Over-expression of insulin-like growth factor 2 mRNA binding protein 3 (IMP3) is correlated with poor prognosis in pancreatic ductal adenocarcinoma (PDAC). Previous studies examining other cancer types have im...

    Clarissa C Pasiliao, Che-Wei A Chang, Brent W Sutherland, Shannon M Valdez… in BMC Cancer (2015)

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    Article

    Akt phosphorylates the Y-box binding protein 1 at Ser102 located in the cold shock domain and affects the anchorage-independent growth of breast cancer cells

    Akt/PKB is a serine/threonine kinase that promotes tumor cell growth by phosphorylating transcription factors and cell cycle proteins. There is particular interest in finding tumor-specific substrates for Akt ...

    Brent W Sutherland, Jill Kucab, Joyce Wu, Cathy Lee, Maggie C U Cheang… in Oncogene (2005)