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Open AccessProviding a Rigorous Benchmark Measurement Foundation for Modeling-Informed Qualification and Certification of Metal Additive Manufactured Components
Metal additive manufacturing (AM) is a transformative set of technologies that are increasingly being used for demanding structural applications. However, persistent challenges regarding reliability and proper...
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Open AccessStrong protective effect of the APOL1 p.N264K variant against G2-associated focal segmental glomerulosclerosis and kidney disease
African Americans have a significantly higher risk of develo** chronic kidney disease, especially focal segmental glomerulosclerosis -, than European Americans. Two coding variants (G1 and G2) in the APOL1 gene...
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Inaxaplin for the treatment of APOL1-associated kidney disease
APOL1 risk variants are associated with an increased risk of chronic kidney disease. Findings from a new study demonstrate that a small molecule, inaxaplin, inhibits APOL1 channel function; furthermore, inaxaplin...
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Promoting Data Science in Mechanical Engineering Research and Education: An Exploration of the Hackathon Mechanism
In 2020, the American Society of Mechanical Engineers successfully held the first series of hackathon events in its two primary conferences. The first was held from August 15–16 as a pre-conference event of th...
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Open AccessNumerical Evaluation of Advanced Laser Control Strategies Influence on Residual Stresses for Laser Powder Bed Fusion Systems
Process-dependent residual stresses are one of the main burdens to a widespread adoption of laser powder bed fusion technology in industry. Residual stresses are directly influenced by process parameters, such...
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Measurements of Melt Pool Geometry and Cooling Rates of Individual Laser Traces on IN625 Bare Plates
The complex physical nature of the laser powder bed fusion (LPBF) process warrants use of multiphysics computational simulations to predict or design optimal operating parameters or resultant part qualities su...
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Outcomes and Conclusions from the 2018 AM-Bench Measurements, Challenge Problems, Modeling Submissions, and Conference
The Additive Manufacturing Benchmark (AM-Bench) test series was established to provide rigorous measurement test data for validating additive manufacturing (AM) simulations for a broad range of AM technologies...
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Influence of scan strategy and process parameters on microstructure and its optimization in additively manufactured nickel alloy 625 via laser powder bed fusion
Laser powder bed fusion (L-PBF) as an additive manufacturing process produces nearly fully dense nickel alloy 625 (IN625) parts with complex features. L-PBF generates surfaces and microstructure through direct...
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Open AccessDysregulation of WTI (−KTS) is Associated with the Kidney-Specific Effects of the LMX1B R246Q Mutation
Mutations in the LIM homeobox transcription factor 1-beta (LMX1B) are a cause of nail patellar syndrome, a condition characterized by skeletal changes, glaucoma and focal segmental glomerulosclerosis. Recently, a...
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Open AccessReishiMax, mushroom based dietary supplement, inhibits adipocyte differentiation, stimulates glucose uptake and activates AMPK
Obesity is a health hazard which is closely associated with various complications including insulin resistance, hypertension, dyslipidemia, atherosclerosis, type 2 diabetes and cancer. In spite of numerous pre...
