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Article
LKB1 phosphorylation and deactivation in lung cancer by NNAL, a metabolite of tobacco-specific carcinogen, in an isomer-dependent manner
LKB1 loss of function is one key oncogenic event in lung cancer. Clinical data suggest that LKB1 loss of function is associated with patients’ smoking status. The responsible ingredients and molecular mechanis...
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Article
Open AccessAutomated next-generation profiling of genomic alterations in human cancers
The lack of validated, distributed comprehensive genomic profiling assays for patients with cancer inhibits access to precision oncology treatment. To address this, we describe elio tissue complete, which has ...
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Open AccessAuthor Correction: A systematic genome-wide map** of oncogenic mutation selection during CRISPR-Cas9 genome editing
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Article
Open AccessA systematic genome-wide map** of oncogenic mutation selection during CRISPR-Cas9 genome editing
Recent studies have reported that genome editing by CRISPR–Cas9 induces a DNA damage response mediated by p53 in primary cells hampering their growth. This could lead to a selection of cells with pre-existing p53
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Article
Open AccessA comprehensive map of alternative polyadenylation in African American and European American lung cancer patients
Deciphering the post-transcriptional mechanisms (PTM) regulating gene expression is critical to understand the dynamics underlying transcriptomic regulation in cancer. Alternative polyadenylation (APA)—regulat...
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Open AccessAuthor Correction: Interaction between the microbiome and TP53 in human lung cancer
Following publication of the original paper [1], the authors submitted a new Additional file 5 to replace the one containing formatting issues. The updated Additional file 5 is published in this correction.
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Open AccessAuthor Correction: Recurrent PTPRT/JAK2 mutations in lung adenocarcinoma among African Americans
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Higher prevalence of homologous recombination deficiency in tumors from African Americans versus European Americans
To improve our understanding of longstanding disparities in incidence and mortality in lung cancer across ancestry, we performed a systematic comparative analysis of molecular features in tumors from African A...
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Article
Open AccessRecurrent PTPRT/JAK2 mutations in lung adenocarcinoma among African Americans
Reducing or eliminating persistent disparities in lung cancer incidence and survival has been challenging because our current understanding of lung cancer biology is derived primarily from populations of Europ...
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Article
Relationship between West African ancestry with lung cancer risk and survival in African Americans
African Americans, especially men, have a higher incidence of lung cancer compared with all other racial and ethnic groups in the US. Self-reported race is frequently used in genomic research studies to captur...
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Article
Open AccessIFNL4-ΔG is associated with prostate cancer among men at increased risk of sexually transmitted infections
Sexually transmitted infections can reach the prostate gland where their harmful effects are mediated by innate immunity, including interferons. Humans are polymorphic for the germline dinucleotide variant, rs...
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Article
Open AccessInteraction between the microbiome and TP53 in human lung cancer
Lung cancer is the leading cancer diagnosis worldwide and the number one cause of cancer deaths. Exposure to cigarette smoke, the primary risk factor in lung cancer, reduces epithelial barrier integrity and in...
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Article
Open AccessAssessment of Variability in the SOMAscan Assay
SOMAscan is an aptamer-based proteomics assay capable of measuring 1,305 human protein analytes in serum, plasma, and other biological matrices with high sensitivity and specificity. In this work, we present a...
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Article
Open AccessMDM2 promoter SNP55 (rs2870820) affects risk of colon cancer but not breast-, lung-, or prostate cancer
Two functional SNPs (SNP285G > C; rs117039649 and SNP309T > G; rs2279744) have previously been reported to modulate Sp1 transcription factor binding to the promoter of the proto-oncogene MDM2, and to influence ca...
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Article
Open AccessAsymmetric segregation of template DNA strands in basal-like human breast cancer cell lines
Stem or progenitor cells from healthy tissues have the capacity to co-segregate their template DNA strands during mitosis. Here, we set out to test whether breast cancer cell lines also possess the ability to ...
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Erratum: Genetic variation in microRNA networks: the implications for cancer research
Nature Reviews Cancer 10, 389–402 (2010) There were several mistakes in TABLES 1–3 of this article. In TABLE 1 on page 385, for rs2910164 in hepatocelluar carcinoma the odds ratio data refer to males only. For...
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Genetic variation in microRNA networks: the implications for cancer research
Single nucleotide polymorphisms (SNPs) in microRNA (miRNA) genes (miR-SNPs) can be predicted to affect function by modulating the transcription of the primary ...
