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  1. No Access

    Article

    Changes in the levels of human tropomyosins IEF 52,55, and 56 do not correlate with the loss of actin cables observed in SV 40 transformed MRC-5 fibroblasts

    A mouse monoclonal antibody (mAb 1D122G9) raised against human tropomyosin IEF 52 (HeLa protein catalogue number, Mr=35 kd) has been characterized both in terms of specificity and patterns of immunofluorescenc...

    J. E. Celis, Borbala Gesser, J. V. Small, S. Nielsen, Ariana Celis in Protoplasma (1986)

  2. Chapter

    Human Cellular Protein Patterns and Their Link to Genome DNA Map** and Sequencing Data: Towards an Integrated Approach to the Study of Gene Expression

    The haploid human genome consists of 3 × 109 base pairs of DNA distributed in 23 distinct chromosomes. Current estimates indicate that there are about 50,000 to 100,000 genes with perhaps 2,000 to 4,000 genes in ...

    Julio E. Celis, Hanne H. Rasmussen, Henrik Leffers, Peder Madsen… in Genetic Engineering (1993)

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  3. No Access

    Article

    1α,25(OH)2D3 regulates NF-κB DNA binding activity in cultured normal human keratinocytes through an increase in IκBα expression

    NF-κB is a dimeric transcription factor which regulates transcription of a number of different genes including IL-8 and p53. In resting cells NF-κB is usually retained in an inactive state in the cytoplasm thr...

    Jette L. Riis, Claus Johansen, Borbala Gesser… in Archives of Dermatological Research (2004)

  4. No Access

    Article

    IL-8 and p53 are inversely regulated through JNK, p38 and NF-κB p65 in HepG2 cells during an inflammatory response

    It is reported that Nuclear factor-κB (NF-κB) activation is dysregulated in chronic inflammatory diseases like psoriasis, rheumatoid arthritis and cancer, resulting in an over expression of pro-inflammatory cy...

    M. K. Rasmussen, L. Iversen, C. Johansen, J. Finnemann… in Inflammation Research (2008)

  5. Article

    Open Access

    Dimethyl fumarate is an allosteric covalent inhibitor of the p90 ribosomal S6 kinases

    Dimethyl fumarate (DMF) has been applied for decades in the treatment of psoriasis and now also multiple sclerosis. However, the mechanism of action has remained obscure and involves high dose over long time o...

    Jacob Lauwring Andersen, Borbala Gesser, Erik Daa Funder… in Nature Communications (2018)

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