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Article
Investigation of the local delivery of an intelligent chitosan-based 188Re thermosensitive in situ-forming hydrogel in an orthotopic hepatoma-bearing rat model
In this study, in vitro and in vivo evaluations of the local delivery of 188Re-Tin colloid and doxorubicin (Dox) through chitosan (C)-based thermosensitive in situ-forming hydrogels by intratumoral injection in a...
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Article
An approach in exploring the fundamental dosimetric characteristics for a long shelf life irradiated acrylamide-based gel
In this study, a long shelf life irradiated gel made from a low-toxicity N-isopropylacrylamide (NIPAM) monomer was used to study the dosimetric characteristics associated with magnetic resonance imaging (MRI). Sp...
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Article
Local delivery of rhenium-188 colloid into hepatic tumor sites in rats using thermo-sensitive chitosan hydrogel: effects of gelling time of chitosan as delivery system
A previously developed internal radiation therapy mode adopting a thermo-sensitive, chitosan-based hydrogel intended for local delivery of 188Re–Tin colloid drug was extended to test for its applicability to the ...
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Article
Optimal composition of a new polymer gel dosimeter-DEMBIG
Polymeric gel dosimeters are used to verify three-dimensional (3D) dose distributions of various types of radiotherapy treatments, particularly radiosurgery. The present paper investigates the low toxicity and...
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Article
Relationship between the level of essential metal elements in human hair and coronary heart disease
Studies on epidemics have demonstrated the relationship between coronary heart disease (CHD) and mineral substances, such as selenium, calcium, magnesium, sodium, potassium, copper, zinc, iron, manganese, and ...
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Article
Preliminary investigation of a new type of propylene based gel dosimeter (DEMBIG)
Radiotherapy widely uses the polymer gel dosimeter. The advantage of polymer gel dosimetry is the mapped 3D absorbed dose distribution that other dosimeters cannot achieve. The Acrylamide (AAm) is a frequently...
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Article
Influence of the particle size of activated charcoal on labeling efficiency with 67Ga-citrate for colonic transit study
Indium-111 and 99mTc have been proposed for colonic transit study, but 111In is expensive and the half-life of 99mTc is too short for the study. Gallium-67 citrate is inexpensive and has a suitable half-life. In ...
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Article
Production of carrier-free 188Re in the past ten years in Taiwan
Twenty clinical scale alumina-based 188W/188Re generators and carrier-free 188Re has been produced at the Institute of Nuclear Energy Research (INER-Taiwan) for over ten years. 2845.6 GBq (76.9 Ci) of 188Re-perrh...
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Chapter and Conference Paper
The Study of propylene acid derivatives polymer gel
The aims of this study were to develop a low toxicity and high dose response gel. Its characteristics include the gel dosimeter sensitivity and high dose response from gel. The DEMBIG gel was polymerized from ...
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Article
A new technique for labeling of Lipiodol with 188Re in the treatment of hepatic tumor
A new method for the synthesis of 188Re-Lipiodol without using a chelating agent and to evaluate the stability and biodistribution of the new agent in rats with hepatic tumors was attempted. Eighteen male Sprague...
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Article
Vascular responses to endovascular irradiation of 188Re in the rabbit model after angioplasty
The effects on vascular restenosis of intravascular radiation delivery from 188Rhenium (Re)-perrhenate liquid-filled balloon through beta-particle radiation are controversial. To determine the effect of beta-radi...
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Article
Evaluation of three rhenium-188 candidates for intravascular radiation therapy with liquid-filled balloons to prevent restenosis
Intravascular brachytherapy is an effective method for inhibiting coronary restenosis after percutaneous transluminal coronary angioplasty. A new concept for preventing restenosis is the use of a liquid-filled...
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Article
Application of macroautoradiography and instantimage in radiopharmaceutical research
The evaluation of the pharmacokinetics of pure, beta radiopharmaceuticals is not possible with scintigraphy. Both whole-body autoradiography (WBAR) and Packard Instantimager, a device for rapid imaging, were u...
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Article
Rhenium-188 hydroxyethylidene diphosphonate: a new generator-produced radiotherapeutic drug of potential value for the treatment of bone metastases
The search for an ideal radioisotope for systemic radiotherapy continues. As a generator-produced radioisotope emitting both beta and gamma rays and having a short physical half-life of 16.9 h, rhenium-188 is ...
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Article
Biodistribution of rhenium-188 Lipiodol infused via the hepatic artery of rats with hepatic tumours
The purpose of this study was to analyse the biodistribution of rhenium-188 Lipiodol in rats with hepatic tumours following intrahepatic arterial injection to assess the potential of188Re-Lipiodol as a radiopharm...
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Article
Rhenium-188 sulphur colloid as a radiation synovectomy agent
Radiation synovectomy has been shown to be an effective treatment for the rheumatoid arthritic knee. In this study, we evaluated the suitability of rhenium-188 as a radiation synovectomy agent. In addition, we...
