8 Result(s)
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Article
Distinct enhancer signatures in the mouse gastrula delineate progressive cell fate continuum during embryo development
Primary germ layers have the potential to form all tissues in the mature organism, and their formation during gastrulation requires precise epigenetic modulation of both proximal and distal regulatory elements...
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Publisher Correction: Single-cell multi-omics sequencing of human early embryos
In the version of this Resource originally published, owing to a technical error an incorrect file was used for Supplementary Table 2; this has now been replaced with the correct file.
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Single-cell multi-omics sequencing of human early embryos
DNA methylation, chromatin states and their interrelationships represent critical epigenetic information, but these are largely unknown in human early embryos. Here, we apply single-cell chromatin overall omic...
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Article
Silencing of developmental genes by H3K27me3 and DNA methylation reflects the discrepant plasticity of embryonic and extraembryonic lineages
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Article
Open AccessATF6 safeguards organelle homeostasis and cellular aging in human mesenchymal stem cells
Loss of organelle homeostasis is a hallmark of aging. However, it remains elusive how this occurs at gene expression level. Here, we report that human mesenchymal stem cell (hMSC) aging is associated with dysf...
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Open AccessSingle-cell multi-omics sequencing of mouse early embryos and embryonic stem cells
Single-cell epigenome sequencing techniques have recently been developed. However, the combination of different layers of epigenome sequencing in an individual cell has not yet been achieved. Here, we develope...
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Article
Open AccessDNA methylation and chromatin accessibility profiling of mouse and human fetal germ cells
Chromatin remodeling is important for the epigenetic reprogramming of human primordial germ cells. However, the comprehensive chromatin state has not yet been analyzed for human fetal germ cells (FGCs). Here w...
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Article
Open AccessSingle-cell triple omics sequencing reveals genetic, epigenetic, and transcriptomic heterogeneity in hepatocellular carcinomas
Single-cell genome, DNA methylome, and transcriptome sequencing methods have been separately developed. However, to accurately analyze the mechanism by which transcriptome, genome and DNA methylome regulate ea...
