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Open AccessSestrins are evolutionarily conserved mediators of exercise benefits
Exercise is among the most effective interventions for age-associated mobility decline and metabolic dysregulation. Although long-term endurance exercise promotes insulin sensitivity and expands respiratory ca...
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Open AccessConcurrent activation of growth factor and nutrient arms of mTORC1 induces oxidative liver injury
mTORC1 is a protein kinase important for metabolism and is regulated by growth factor and nutrient signaling pathways, mediated by the Rheb and Rag GTPases, respectively. Here we provide the first animal model...
