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Article
Open AccessTauopathy promotes spinal cord-dependent production of toxic amyloid-beta in transgenic monkeys
Tauopathy, characterized by the hyperphosphorylation and accumulation of the microtubule-associated protein tau, and the accumulation of Aβ oligomers, constitute the major pathological hallmarks of Alzheimer’s...
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Article
Open AccessGeneration of inactivated IL2RG and RAG1 monkeys with severe combined immunodeficiency using base editing
Severe combined immunodeficiency (SCID) encompasses a range of inherited disorders that lead to a profound deterioration of the immune system. Among the pivotal genes associated with SCID, RAG1 and IL2RG play cru...