Skip to main content

3 Result(s)

within Bofeng Han Remove this filter

and

  1. Article

    Open Access

    Tauopathy promotes spinal cord-dependent production of toxic amyloid-beta in transgenic monkeys

    Tauopathy, characterized by the hyperphosphorylation and accumulation of the microtubule-associated protein tau, and the accumulation of Aβ oligomers, constitute the major pathological hallmarks of Alzheimer’s...

    Zhuchi Tu, Sen Yan, Bofeng Han, Caijuan Li… in Signal Transduction and Targeted Therapy (2023)

    Download PDF (6746 KB) View Article

  2. Article

    Open Access

    Generation of inactivated IL2RG and RAG1 monkeys with severe combined immunodeficiency using base editing

    Severe combined immunodeficiency (SCID) encompasses a range of inherited disorders that lead to a profound deterioration of the immune system. Among the pivotal genes associated with SCID, RAG1 and IL2RG play cru...

    **ao Zheng, Chunhui Huang, Yingqi Lin… in Signal Transduction and Targeted Therapy (2023)

    Download PDF (5671 KB) View Article

  3. No Access

    Article

    Cas9-mediated replacement of expanded CAG repeats in a pig model of Huntington’s disease

    The monogenic nature of Huntington’s disease (HD) and other neurodegenerative diseases caused by the expansion of glutamine-encoding CAG repeats makes them particularly amenable to gene therapy. Here we show t...

    Sen Yan, **ao Zheng, Yingqi Lin, Caijuan Li, Zhaoming Liu… in Nature Biomedical Engineering (2023)