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  1. Article

    Open Access

    Tauopathy promotes spinal cord-dependent production of toxic amyloid-beta in transgenic monkeys

    Tauopathy, characterized by the hyperphosphorylation and accumulation of the microtubule-associated protein tau, and the accumulation of Aβ oligomers, constitute the major pathological hallmarks of Alzheimer’s...

    Zhuchi Tu, Sen Yan, Bofeng Han, Caijuan Li… in Signal Transduction and Targeted Therapy (2023)

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  2. Article

    Open Access

    Generation of inactivated IL2RG and RAG1 monkeys with severe combined immunodeficiency using base editing

    Severe combined immunodeficiency (SCID) encompasses a range of inherited disorders that lead to a profound deterioration of the immune system. Among the pivotal genes associated with SCID, RAG1 and IL2RG play cru...

    **ao Zheng, Chunhui Huang, Yingqi Lin… in Signal Transduction and Targeted Therapy (2023)

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