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BEHAV3D: a 3D live imaging platform for comprehensive analysis of engineered T cell behavior and tumor response

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  1. Article

    Open Access

    A systematic review on the effectiveness of robot-assisted minimally invasive gastrectomy

    Robot-assisted minimally invasive gastrectomy (RAMIG) is increasingly used as a surgical approach for gastric cancer. This study assessed the effectiveness of RAMIG and studied which stages of the IDEAL-framew...

    L. Triemstra, R. B. den Boer, M. M. Rovers, C. E. V. B. Hazenberg in Gastric Cancer (2024)

  2. Article

    Open Access

    Gemcitabine as chemotherapy of head and neck cancer in Fanconi anemia patients

    Fanconi anemia (FA) is a rare hereditary disease resulting from an inactivating mutation in the FA/BRCA pathway, critical for the effective repair of DNA interstrand crosslinks (ICLs). The disease is character...

    Anne M. van Harten, Ronak Shah, D. Vicky de Boer, Marijke Buijze in Oncogenesis (2024)

  3. Article

    Open Access

    Study Protocol: Pegasus: psychotherapy incorporating horses for ‘therapy-resistant’ adolescents with autism spectrum disorders, a study with series of randomised, baseline controlled n-of-1 trials

    For people with autism spectrum disorder (ASD), daily life can be highly stressful with many unpredictable events that can evoke emotion dysregulation (ED): a strong difficulty with appropriately negative affe...

    Jenny C. den Boer, Helen Klip, Anita Blonk, Monique Lenselink in BMC Psychiatry (2024)

  4. Article

    Open Access

    A complete chromosome substitution map** panel reveals genome-wide epistasis in Arabidopsis

    Chromosome substitution lines (CSLs) are tentatively supreme resources to investigate non-allelic genetic interactions. However, the difficulty of generating such lines in most species largely yielded imperfec...

    Cris L. Wijnen, Ramon Botet, José van de Belt, Laurens Deurhof, Hans de Jong in Heredity (2024)

  5. Article

    Open Access

    Short and long-term acceptability and efficacy of extended-release cornstarch in the hepatic glycogen storage diseases: results from the Glyde study

    Hypoglycaemia is the primary manifestation of all the hepatic types of glycogen storage disease (GSD). In 2008, Glycosade®, an extended-release waxy maize cornstarch, was reported as an alternative to uncooked co...

    Weinstein DA, Jackson RJ, Brennan EA, Williams M in Orphanet Journal of Rare Diseases (2024)

  6. Article

    Open Access

    Let’s talk about work: pilot study of an education program on discussing work participation with cancer patients for general practitioners in training

    Cancer patients report that they lack support from healthcare providers when it comes to returning to or maintaining employment. In the education of general practitioners (GPs) in the Netherlands, there is lit...

    Mariska de Wit, Kristel M. van Asselt, Marianne Mak-van der Vossen in BMC Medical Education (2024)

  7. Article

    Open Access

    Integration of genetics and MRD to define low risk patients with B-cell precursor acute lymphoblastic leukaemia with intermediate MRD levels at the end of induction

    Anthony V. Moorman, Amir Enshaei, Daniel Murdy, Melvin Joy, Judith M. Boer in Leukemia (2024)

  8. Article

    Open Access

    Page curves and replica wormholes from random dynamics

    We show how to capture both the non-unitary Page curve and replica wormhole-like contributions that restore unitarity in a toy quantum system with random dynamics. The motivation is to find the simplest dynami...

    Jan de Boer, Jildou Hollander, Andrew Rolph in Journal of High Energy Physics (2024)

  9. Article

    Open Access

    Author Correction: Prediction of recurrence risk in endometrial cancer with multimodal deep learning

    Sarah Volinsky-Fremond, Nanda Horeweg, Sonali Andani in Nature Medicine (2024)

  10. Article

    Open Access

    NFL and GFAP in (pre)symptomatic RVCL-S carriers: a monogenic cerebral small vessel disease

    Neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAP) have emerged as biomarkers for cerebral small vessel disease (SVD). We investigated their role in a hereditary SVD model, retinal vasc...

    Annelise E. Wilms, I. de Boer, N. Pelzer, S. G. J. G. in’t Veld in Journal of Neurology (2024)

  11. Article

    Open Access

    Model matchmaking via the Solve-RD Rare Disease Models & Mechanisms Network (RDMM-Europe)

    In biomedical research, particularly for rare diseases (RDs), there is a critical need for model organisms to unravel the mechanistic basis of diseases, perform biomarker studies and develop potential therapeu...

    Kornelia Ellwanger, Julie A. Brill, Elke de Boer, Stephanie Efthymiou in Lab Animal (2024)

  12. Article

    Open Access

    Reducing sectoral hard-to-abate emissions to limit reliance on carbon dioxide removal

    To reach net-zero greenhouse gas targets, carbon dioxide removal (CDR) technologies are required to compensate for residual emissions in the hard-to-abate sectors. However, dependencies on CDR technologies inv...

    Oreane Y. Edelenbosch, Andries F. Hof, Maarten van den Berg in Nature Climate Change (2024)

  13. Article

    Open Access

    Demonstration and Analysis of Conditions to Obtain a High Strength Inconel 625 to Stainless Steel 304L Interface by Directed Energy Deposition

    Functional grading (FG) is often used to bond dissimilar metals. However, that approach is complicated from a manufacturing perspective, and the associated challenges can outweigh the benefits of FG. Here, we ...

    A. J. Stair, Bryan A. Webler, Jack L. Beuth in Metallurgical and Materials Transactions A (2024)

  14. Article

    Open Access

    An atypical case of fatal ‘esophageal apoplexy’: post-mortem findings and differential diagnosis

    Forensic pathologists need to have comprehensive knowledge of a large variety of causes of sudden natural death. We describe a case of sudden and unexpected death in woman in her sixties due to rupture of a la...

    Hans H. de Boer, Chris O’Donnell in International Journal of Legal Medicine (2024)

  15. Article

    Open Access

    Predicting the bodily self in space and time

    To understand how the human brain distinguishes itself from external stimulation, it was examined if motor predictions enable healthy adult volunteers to infer self-location and to distinguish their body from ...

    D. M. L. de Boer, P. J. Johnston, F. Namdar, G. Kerr, A. Cleeremans in Scientific Reports (2024)

  16. Article

    Geschlechterspezifische Aspekte kardiovaskulärer Erkrankungen

    Kardiovaskuläre Erkrankungen sind weltweit sowohl bei Männern als auch bei Frauen die führende Todesursache. Durch fokussierte klinische und wissenschaftliche Untersuchungen hat sich das Verständnis für geschl...

    Prof. Dr. Andrea Baessler, Pascal Bauer, Michael Becker in Die Kardiologie (2024)

  17. Article

    Open Access

    The possible impact of segmenting radiological images on students’ spatial abilities

    Visuospatial ability plays a crucial role in anatomy related study success as studies have shown that students with high scores on a mental rotation test (MRT) perform better on anatomy exams. We hypothesized ...

    Jort Karstens, Lucas Boer, Thomas Maal, Dylan Henssen in Discover Education (2024)

  18. Article

    Open Access

    Bacteriophage ISP eliminates Staphylococcus aureus in planktonic phase, but not in the various stages of the biofilm cycle

    Metal-implant associated bacterial infections are a major clinical problem due to antibiotic treatment failure. As an alternative, we determined the effects of bacteriophage ISP on clinical isolates of Staphyloco...

    Mariëlle Verheul, Aat A. Mulder, Sven C. J. van Dun in Scientific Reports (2024)

  19. Article

    Open Access

    Negotiating becoming: a Nietzschean critique of large language models

    Large language models (LLMs) structure the linguistic landscape by reflecting certain beliefs and assumptions. In this paper, we address the risk of people unthinkingly adopting and being determined by the val...

    Simon W. S. Fischer, Bas de Boer in Ethics and Information Technology (2024)

  20. Article

    Open Access

    Amplitude analysis of the \( {\Lambda}_{\textrm{b}}^0\to {\textrm{pK}}^{-}\upgamma \) decay

    The resonant structure of the radiative decay Λ b 0 ...

    R. Aaij, A. S. W. Abdelmotteleb, C. Abellan Beteta in Journal of High Energy Physics (2024)

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