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Article
Responses of Chrysanthemum Cells to Mechanical Stimulation Require Intact Microtubules and Plasma Membrane–Cell Wall Adhesion
Plant cells are highly susceptible and receptive to physical factors, both in nature and under experimental conditions. Exposure to mechanical forces dramatically results in morphological and microstructural a...
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Article
DNA binding and oxidative DNA damage induced by a quercetin copper(II) complex: potential mechanism of its antitumor properties
The interaction of a quercetin copper(II) complex with DNA was investigated using UV–vis spectra, fluorescence measurement, viscosity measurement, agarose gel electrophoresis, and thiobarbituric acid reactive ...
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Article
A novel method for preparing electrospun fibers with nano-/micro-scale porous structures
Electrospun fibers with nano-/micro-scale porous structures were successfully fabricated from polymer solutions that contained suspended micro-/nano-size salt particles of sodium chloride or calcium carbonate,...
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Article
From GC-rich DNA binding to the repression of survivin gene for quercetin nickel (II) complex: implications for cancer therapy
The DNA binding and cleavage properties of quercetin nickel (II) complex have been studied, but little attention has been devoted to the relationship between antitumor activity of this complex and DNA-binding ...
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Article
Electrospun composite nanofibers containing nanoparticles for the programmable release of dual drugs
In this study, electrospun composite nanofibers containing nanoparticles for the programmable release of dual drugs were successfully fabricated through a one-step, single-nozzle electrospinning technique. Fie...
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Article
Impurity analysis of gentamicin bulk samples by improved liquid chromatography-ion trap mass spectrometry
Several gentamicin bulk samples from different origins were investigated using an LC/MS method. LC equipped with ion trap MS with positive ionization was performed on a Capcell Pak C18 (AQ) column with the mobile...
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Article
CML24 is Involved in Root Mechanoresponses and Cortical Microtubule Orientation in Arabidopsis
Mechanostimuli can influence plant root system architecture by causing alterations in the root tip growth direction and triggering lateral root initiation. However, how a plant root senses and translates mecha...
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Article
Biological Swarm Intelligence Based Opportunistic Resource Allocation for Wireless Ad Hoc Networks
Particle swarm optimization (PSO) is one of the most important biological swarm intelligence paradigms. However, the standard PSO algorithm can easily get trapped in the local optima when solving complex multi...
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Article
Fabrication of core–shell micro/nanoparticles for programmable dual drug release by emulsion electrospraying
The study aimed at constructing a novel drug delivery system for programmable multiple drug release controlled with core–shell structure. The core–shell structure consisted of chitosan nanoparticles as core an...
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Article
Enteric-coated sustained-release nanoparticles by coaxial electrospray: preparation, characterization, and in vitro evaluation
Enteric-coated formulations can delay the release of drugs until they have passed through the stomach. However, high concentration of drugs caused by rapidly released in the small intestine leads to the intest...
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Article
Open AccessGlucosidase inhibitory activity and antioxidant activity of flavonoid compound and triterpenoid compound from Agrimonia Pilosa Ledeb
In Chinese traditional medicine, Agrimonia pilosa Ledeb (APL) exhibits great effect on treatment of type 2 diabetes mellitus (T2DM), however its mechanism is still unknown. Considering that T2DM are correlated wi...
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Article
Microtubule dynamics is required for root elongation growth under osmotic stress in Arabidopsis
Osmotic stress caused by drought and soil salinity is one of the factors that affect plant root system growth and development. Previous studies have shown that microtubule plays a critical role in plant roots ...
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Article
A Micromechanics Model for Turgor Pressure of Arabidopsis thaliana Protoplast
Understanding the key role of turgor pressure in plant growth and development is important for recognizing the mechanical behavior of plant cell wall material deposition. In this study, we developed a micromec...
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Article
Open AccessThe three-dimensional structure of Clostridium absonum 7α-hydroxysteroid dehydrogenase: new insights into the conserved arginines for NADP(H) recognition
7α-hydroxysteroid dehydrogenase (7α-HSDH) can catalyse the oxidation of C7 α-OH of the steroid nucleus in the bile acid metabolism. In the paper we determined the crystal structure of 7α-HSDH from Clostridium abs...
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Article
Open AccessEffects of nitrogen availability on polymalic acid biosynthesis in the yeast-like fungus Aureobasidium pullulans
Polymalic acid (PMA) is a novel polyester polymer that has been broadly used in the medical and food industries. Its monomer, L-malic acid, is also a potential C4 platform chemical. However, little is known ab...
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Article
A novel perspective on neuron study: damaging and promoting effects in different neurons induced by mechanical stress
A growing volume of experimental evidence demonstrates that mechanical stress plays a significant role in growth, proliferation, apoptosis, gene expression, electrophysiological properties and many other aspec...
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Article
Comparative analysis of the gut microbiota of black bears in China using high-throughput sequencing
The Asiatic black bear (Ursus thibetanus) is a protected species from eastern Asia. In China, the Asiatic black bear occurs in 17 provinces from northeast to southwest regions. To date, information on microbial d...
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Article
Open AccessDiscovery of tauroursodeoxycholic acid biotransformation enzymes from the gut microbiome of black bears using metagenomics
Tauroursodeoxycholic acid (TUDCA) has been used to treat many diseases effectively. 7α-hydroxysteroid dehydrogenase (7α-HSDH) and 7β-hydroxysteroid dehydrogenase (7β-HSDH) are two key enzymes that drive the ef...
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Article
A root penetration model of Arabidopsis thaliana in phytagel medium with different strength
Phytagel media were evaluated as systems to mechanically impede roots of A. thaliana. Studying mechanical properties of Phytagel and exploring the root response to mechanical stimulation can facilitate plant cult...
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Article
The effects of flavonoid compound from Agrimonia pilosa Ledeb on promotting 3T3-L1 preadipocytes differentiation by activating PPARγ partially
This study aimed to investigate the mechanism of intervening type II diabetes by flavonoid compound from Agrimonia pilosa Ledeb in vitro. We found flavonoid compound exhibited moderate peroxisome proliferator-act...
