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Article
Global synergistic actions to improve brain health for human development
The global burden of neurological disorders is substantial and increasing, especially in low-resource settings. The current increased global interest in brain health and its impact on population wellbeing and ...
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Article
Open AccessAccuracy of automated intracerebral hemorrhage volume measurement on non-contrast computed tomography: a Swedish Stroke Register cohort study
Hematoma volume is the strongest predictor of patient outcome after intracerebral hemorrhage (ICH). The aim of this study was to validate novel fully automated software for quantification of ICH volume on non-...
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Article
Open AccessEndovascular therapy in basilar artery occlusion in Sweden 2016–2019—a nationwide, prospective registry study
We present the first nationwide study on endovascular therapy for basilar artery occlusion (BAO) from early hospital management to 3-month outcome.
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Article
Open AccessLate stroke after transcatheter aortic valve replacement: a nationwide study
Transcatheter aortic valve replacement (TAVR) is a rapidly growing field. Short-term safety and efficacy of these procedures have been studied extensively. However, little is known about the safety of these de...
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Article
Platelet function/reactivity testing and prediction of risk of recurrent vascular events and outcomes after TIA or ischaemic stroke: systematic review and meta-analysis
The prevalence of ex vivo ‘high on-treatment platelet reactivity (HTPR)’ and its relationship with recurrent vascular events/outcomes in patients with ischaemic cerebrovascular disease (CVD) is unclear.
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Article
Relationship of White Matter Lesions with Intracerebral Hemorrhage Expansion and Functional Outcome: MISTIE II and CLEAR III
Intracerebral hemorrhage (ICH) patients commonly have concomitant white matter lesions (WML) which may be associated with poor outcome. We studied if WML affects hematoma expansion (HE) and post-stroke functio...
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Article
Open AccessDifferences in self-perceived general health, pain, and depression 1 to 5 years post-stroke related to work status at 1 year
Stroke is one of the most common diseases and has several potential consequences, such as psychological problems and pain. Return to work (RTW) after stroke in working-age individuals is incomplete. The presen...
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Article
Open AccessCorrection to: Update on the EFFECTS study of fluoxetine for stroke recovery: a randomised controlled trial in Sweden
Following publication of the original article [1], we were notified that one of the corresponding author’s affiliations was omitted.
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Article
Open AccessSocioeconomic status and survival after stroke – using mediation and sensitivity analyses to assess the effect of stroke severity and unmeasured confounding
Although it has been established that low socioeconomic status is linked to increased risk of death after stroke, the mechanisms behind this link are still unclear. In this study we aim to shed light on the re...
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Open AccessUpdate on the EFFECTS study of fluoxetine for stroke recovery: a randomised controlled trial in Sweden
Studies have suggested that fluoxetine might improve neurological recovery after stroke, but the results remain inconclusive. The EFFECTS (Efficacy oF Fluoxetine – a randomisEd Controlled Trial in Stroke) reac...
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Article
Stroke management — recent advances and residual challenges
The past year saw progress in acute treatment of ischaemic stroke, but large inequalities in stroke services were revealed, warranting strategical initiatives to improve treatment access. Reclassification of s...
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Open AccessTiming of oral anticoagulant therapy in acute ischemic stroke with atrial fibrillation: study protocol for a registry-based randomised controlled trial
Oral anticoagulation therapy is recommended for the prevention of recurrent ischemic stroke in patients with atrial fibrillation (AF). Current guidelines do not provide evidence-based recommendations on optima...
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Article
Open AccessSpontaneous Recovery of Upper Extremity Motor Impairment After Ischemic Stroke: Implications for Stem Cell-Based Therapeutic Approaches
Preclinical studies suggest that stem cell therapy (SCT) may improve sensorimotor recovery after stroke. Upper extremity motor impairment (UEMI) is common after stroke, often entailing substantial disability. ...
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Article
Open AccessPreHospital Ambulance Stroke Test - pilot study of a novel stroke test
There is a need for a prehospital stroke test that in addition to high sensitivity for stroke, also is able to communicate stroke severity similar to the National Institute of Health Stroke Scale (NIHSS).
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Article
Prevention of stroke: a strategic global imperative
Although global stroke incidence and mortality declined from 1990 to 2013, the stroke burden, in terms of absolute numbers of people affected by stroke, contin...
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Article
Frequency of MELAS main mutation in a phenotype-targeted young ischemic stroke patient population
Mitochondrial diseases, predominantly mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS), may occasionally underlie or coincide with ischemic stroke (IS) in young and middle-age...
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Article
Open AccessLessons from everyday stroke care for clinical research and vice versa: comparison of a comprehensive and a research population of young stroke patients
Translating knowledge derived from medical research into the clinical setting is dependent on the representativeness of included patients. Therefore we compared baseline data of patients included in a recent l...
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Article
Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke
Hugh Markus, Peter Donnelly and colleagues report a genome-wide association study for ischemic stroke. They identify a SNP in HDAC9, a histone deacetylase gene, that is associated with large vessel ischemic strok...
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Article
Explorative investigation of biomarkers of brain damage and coagulation system activation in clinical stroke differentiation
A simple and accurate method of differentiating ischemic stroke and intracerebral hemorrhage (ICH) is potentially useful to facilitate acute therapeutic management. Blood measurements of biomarkers of brain da...
