Immune Responses to Biosurfaces
Mechanisms and Therapeutic Interventions
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Article
Open AccessStent coating containing a charged silane coupling agent that regulates protein adsorption to confer antithrombotic and cell-adhesion properties
The evolution of endovascular therapies, particularly in the field of intracranial aneurysm treatment, has been truly remarkable and is characterized by the development of various stents. However, ischemic com...
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Article
Genetic determinants of mannose-binding lectin activity predispose to thromboembolic complications in critical COVID-19
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Article
Open AccessBlood compatibility of widely used central venous catheters; an experimental study
An inserted central venous catheter (CVC) is considered foreign material by the inert host defence systems and induce inflammation and thrombus formation. The objective of this study was to evaluate blood comp...
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Article
Open AccessComplement as driver of systemic inflammation and organ failure in trauma, burn, and sepsis
Complement is one of the most ancient defense systems. It gets strongly activated immediately after acute injuries like trauma, burn, or sepsis and helps to initiate regeneration. However, uncontrolled complem...
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Article
Immunopathophysiology of trauma-related acute kidney injury
Physical trauma can affect any individual and is globally accountable for more than one in every ten deaths. Although direct severe kidney trauma is relatively infrequent, extrarenal tissue trauma frequently r...
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Protocol
Quantification of Complement Proteins with Special Reference to C1q: Multiplex Versus ELISA Versus Rocket Immunoelectrophoresis Versus Nephelometry
Accurate determination of complement component C1q is hampered by the fact that C1q is an immune complex binding protein. Consequently, immunochemical techniques which rely on immune complex formation in fluid...
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Article
Open AccessBlood type A associates with critical COVID-19 and death in a Swedish cohort
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Article
Open AccessObstacles to intergenerational communication in caregivers’ narratives regarding young people’s sexual and reproductive health and lifestyle in rural South Africa
Statistics from South Africa show the world’s highest HIV prevalence with an estimated seven million people living with the virus. Several studies have pointed to communication about sexuality between parents/...
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Article
‘Stealth’ corporate innovation: an emerging threat for therapeutic drug development
Therapeutic innovations of potentially great clinical impact should embrace the overarching values of research accountability, data transparency and validation through the scientific peer-review process.
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Article
Author Correction: ‘Stealth’ corporate innovation: an emerging threat for therapeutic drug development
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Open AccessTwo subgroups in systemic lupus erythematosus with features of antiphospholipid or Sjögren’s syndrome differ in molecular signatures and treatment perspectives
Previous studies and own clinical observations of patients with systemic lupus erythematosus (SLE) suggest that SLE harbors distinct immunophenotypes. This heterogeneity might result in differences in response...
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Article
The multifaceted role of complement in kidney transplantation
Increasing evidence indicates an integral role for the complement system in the deleterious inflammatory reactions that occur during critical phases of the transplantation process, such as brain or cardiac dea...
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Article
Open AccessAuthor Correction: Dispersion of TiO2 nanoparticles improves burn wound healing and tissue regeneration through specific interaction with blood serum proteins
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.
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Article
Open AccessAuxiliary activation of the complement system and its importance for the pathophysiology of clinical conditions
Activation and regulation of the cascade systems of the blood (the complement system, the coagulation/contact activation/kallikrein system, and the fibrinolytic system) occurs via activation of zymogen molecul...
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Article
Open AccessDispersion of TiO2 nanoparticles improves burn wound healing and tissue regeneration through specific interaction with blood serum proteins
Burn wounds are one of the most important causes of mortality and especially morbidity around the world. Burn wound healing and skin tissue regeneration remain thus one of the most important challenges facing ...
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Article
Cardiovascular disease in haemodialysis: role of the intravascular innate immune system
Haemodialysis is a life-saving renal replacement modality for end-stage renal disease, but this therapy is associated with an increased risk of cardiovascular ...
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Article
Open AccessComplement receptor 2 is up regulated in the spinal cord following nerve root injury and modulates the spinal cord response
Activation of the complement system has been implicated in both acute and chronic states of neurodegeneration. However, a detailed understanding of this complex network of interacting components is still lacking.
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Book and Conference Proceedings
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Chapter and Conference Paper
Complement Interception Across Humoral Incompatibility in Solid Organ Transplantation: A Clinical Perspective
The humoral barrier in transplant biology is the result of preformed donor-specific antibodies (DSAs), directed either against human leukocyte antigens (HLA) or non-HLA antigens such as blood group (ABO) molec...
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Chapter and Conference Paper
Thromboinflammation in Therapeutic Medicine
Thromboinflammation is primarily triggered by the humoral innate immune system, which mainly consists of the cascade systems of the blood, i.e., the complement, contact/coagulation and fibrinolytic systems. Ac...
