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  1. No Access

    Article

    The transcriptional and regulatory identity of erythropoietin producing cells

    Erythropoietin (Epo) is the master regulator of erythropoiesis and oxygen homeostasis. Despite its physiological importance, the molecular and genomic contexts of the cells responsible for renal Epo production...

    Bjørt K. Kragesteen, Amir Giladi, Eyal David, Shahar Halevi… in Nature Medicine (2023)

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    Article

    Heads or tails: histone tail clip** regulates macrophage activity

    Chromatin undergoes extensive reprogramming during immune cell differentiation. Histone clip**, an underexplored epigenetic mechanism, ensures precise macrophage development and function and is now found to ...

    Bjørt K. Kragesteen, Ido Amit in Nature Immunology (2021)

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    Article

    Variants in KIAA0825 underlie autosomal recessive postaxial polydactyly

    Postaxial polydactyly (PAP) is a common limb malformation that often leads to cosmetic and functional complications. Molecular evaluation of polydactyly can serve as a tool to elucidate genetic and signaling p...

    Irfan Ullah, Naseebullah Kakar, Isabelle Schrauwen, Shabir Hussain… in Human Genetics (2019)

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    Article

    Dynamic 3D chromatin architecture contributes to enhancer specificity and limb morphogenesis

    The regulatory specificity of enhancers and their interaction with gene promoters is thought to be controlled by their sequence and the binding of transcription factors. By studying Pitx1, a regulator of hindlimb...

    Bjørt K. Kragesteen, Malte Spielmann, Christina Paliou, Verena Heinrich… in Nature Genetics (2018)