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Article
Pimarane diterpenes from the Arctic fungus Eutypella sp. D-1
Two new diterpenes, libertellenone G(1) and libertellenone H(2) were isolated from the fungus Eutypella sp. D-1 isolated from the soil of high latitude of Arctic, together with two known pimarane diterpenes (3–4)...
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Article
Targeted induction of apoptosis in glioblastoma multiforme cells by an MRP3-specific TRAIL fusion protein in vitro
Single-chain Fv fragments (scFvs) consist of the variable heavy-chain (VH) and variable light-chain (VL) domains, which are the smallest immunoglobulin fragments containing the whole antigen-binding site. Human s...
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Article
Characterization of a marine-derived dextranase and its application to the prevention of dental caries
The dextranase added in current commercial dextranase-containing mouthwashes is largely from fungi. However, fungal dextranase has shown much higher optimum temperature than bacterial dextranase and relatively...
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Article
Cloning, expression and functional characterization of a novel trehalose synthase from marine Pseudomonas sp. P8005
Trehalose synthase (TreS) catalyzes the reversible interconversion of maltose and trehalose. A novel treS gene with a length of 3,369 bp, encoding a protein of 1,122 amino acid residues with a predicted molecular...
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Article
A novel cold-adapted β-galactosidase isolated from Halomonas sp. S62: gene cloning, purification and enzymatic characterization
A novel 1,170 bp β-galactosidase gene sequence from Halomonas sp. S62 (BGalH) was identified through whole genome sequencing and was submitted to GenBank (Accession No. JQ337961). The BGalH gene was heterologousl...
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Article
Isolation of New Polyketide Synthase Gene Fragments and a Partial Gene Cluster from East China Sea and Function Analysis of a New Acyltransfrase
Using the consensus-degenerate hybrid oligonucleotide primer polymerase chain reaction method, 26 new ketoacyl synthase (KS) fragments were isolated from a marine sediment sample in the East China Sea (ECS) an...
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Article
Expression of soluble, biologically active recombinant human tumstatin in Escherichia coli
Tumstatin, a 28-kDa C-terminal fragment of collagen IV, is a potent anti-angiogenic protein and inhibitor of tumour growth. Recombinant tumstatin was prepared from Escherichia coli deposited as insoluble, inactiv...
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Article
Expression of estrogen receptor (ER) - α and - β transcripts in the neonatal and adult rat cerebral cortex, cerebellum, and olfactory bulb
In the present study expression of estrogen receptor subtype - α(ER α) and - β (ER β) in the cerebral cortex, cerebellum, and olfactory bulb was investigated and compared between neonatal (1 ∼ 3-days-old) and adu...