224 Result(s)
within
Bing-**n Xu
Life Sciences
English
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Article
Open AccessCircadian-driven tissue specificity is constrained under caloric restricted feeding conditions
Tissue specificity is a fundamental property of an organ that affects numerous biological processes, including aging and longevity, and is regulated by the circadian clock. However, the distinction between cir...
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Article
Open AccessSusceptibility gene identification and risk evaluation model construction by transcriptome-wide association analysis for salt sensitivity of blood pressure
Salt sensitivity of blood pressure (SSBP) is an intermediate phenotype of hypertension and is a predictor of long-term cardiovascular events and death. However, the genetic structures of SSBP are uncertain, an...
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Article
Yersinia infection induces glucose depletion and AMPK-dependent inhibition of pyroptosis in mice
Nutritional status and pyroptosis are important for host defence against infections. However, the molecular link that integrates nutrient sensing into pyroptosis during microbial infection is unclear. Here, us...
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Article
Cross-Linking Methods of the Silk Protein Hydrogel in Oral and Craniomaxillofacial Tissue Regeneration
Craniomaxillofacial tissue defects are clinical defects involving craniomaxillofacial and oral soft and hard tissues. They are characterized by defect-shaped irregularities, bacterial and inflammatory environm...
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Open AccessAerobic glycolysis of vascular endothelial cells: a novel perspective in cancer therapy
Vascular endothelial cells (ECs) are monolayers of cells arranged in the inner walls of blood vessels. Under normal physiological conditions, ECs play an essential role in angiogenesis, homeostasis and immune ...
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Article
A neural m6A pathway regulates behavioral aggregation in migratory locusts
RNA N6-methyladenosine (m6A), as the most abundant modification of messenger RNA, can modulate insect behaviors, but its specific roles in aggregation behaviors remain unexplored. Here, we conducted a comprehensi...
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Article
Open AccessCharacterization of the gut microbiota in polycystic ovary syndrome with dyslipidemia
Polycystic ovary syndrome (PCOS) is an endocrinopathy in childbearing-age females which can cause many complications, such as diabetes, obesity, and dyslipidemia. The metabolic disorders in patients with PCOS ...
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Open AccessLncRNA PCED1B-AS1 mediates miR-3681-3p/MAP2K7 axis to promote metastasis, invasion and EMT in gastric cancer
LncRNA PCED1B-AS1 is abnormally expressed in multiple cancers and has been confirmed as an oncogene. Our study aimed to investigate the regulatory mechanism of lncRNA PCED1B-AS1 in gastric cancer.
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Article
Application of 18β-glycyrrhetinic acid in the structural modification of natural products: a review
18β-Glycyrrhetinic acid (GA) is an oleane-type pentacyclic triterpene saponin obtained from glycyrrhizic acid by removing 2 glucuronic acid groups. GA and its analogues are active substances of glycyrrhiza aic...
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Article
Defective prelamin A processing promotes unconventional necroptosis driven by nuclear RIPK1
Defects in the prelamin A processing enzyme caused by loss-of-function mutations in the ZMPSTE24 gene are responsible for a spectrum of progeroid disorders characterized by the accumulation of farnesylated prelam...
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Article
Open AccessMulti-modal molecular determinants of clinically relevant osteoporosis subtypes
Due to a rapidly aging global population, osteoporosis and the associated risk of bone fractures have become a wide-spread public health problem. However, osteoporosis is very heterogeneous, and the existing s...
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Article
Exploring the Potential of Straw and Biochar Application on Soil Quality Indicators and Crop Yield in Semi-arid Regions
Plants being sessile entities are often subjected to varied environmental stresses. In semi-arid regions, abiotic factors like soil erosion, low soil fertility, lack of water-saving strategies, and prolonged d...
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Article
Aerobic exercise mitigates high-fat diet-induced cardiac dysfunction, pyroptosis, and inflammation by inhibiting STING-NLRP3 signaling pathway
Obesity has been identified as an independent risk factor for cardiovascular disease. Recent reports have highlighted the significance of stimulator of interferon genes (STING)-NOD-like receptor protein 3 (NLR...
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Article
Innate immune sensing of lysosomal dysfunction drives multiple lysosomal storage disorders
Lysosomal storage disorders (LSDs), which are characterized by genetic and metabolic lysosomal dysfunctions, constitute over 60 degenerative diseases with considerable health and economic burdens. However, the...
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Article
Reduction of DHHC5-mediated beclin 1 S-palmitoylation underlies autophagy decline in aging
Autophagy is a lysosome-dependent degradation pathway essential for cellular homeostasis, which decreases with age. However, it is unclear how aging induces autophagy decline. Here we show the role of protein S-p...
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Article
Aurora kinase A-mediated phosphorylation triggers structural alteration of Rab1A to enhance ER complexity during mitosis
Morphological rearrangement of the endoplasmic reticulum (ER) is critical for metazoan mitosis. Yet, how the ER is remodeled by the mitotic signaling remains unclear. Here, we report that mitotic Aurora kinase...
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One-time root-zone fertilization of controlled-release urea increases nitrogen use efficiency while reducing nitrogen loss risk in a ratoon rice field under two irrigation practices
Optimizing agronomic management plays a vital role in improving nitrogen (N) use efficiency (NUE) of rice. One-time deep application of fertilizer, especially root-zone fertilization (RZF), has already been re...
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Open AccessTFEB and TFE3 cooperate in regulating inorganic arsenic-induced autophagy-lysosome impairment and immuno-dysfunction in primary dendritic cells
Arsenic (As) is a prevalent and hazardous environmental toxicant associated with cancer and various health problems, which has been shown suppressive effects on dendritic cells (DCs). Autophagy is essential fo...
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Open AccessCan urban forests provide acoustic refuges for birds? Investigating the influence of vegetation structure and anthropogenic noise on bird sound diversity
As a crucial component of terrestrial ecosystems, urban forests play a pivotal role in protecting urban biodiversity by providing suitable habitats for acoustic spaces. Previous studies note that vegetation st...
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Article
Open AccessLipid parameters, adipose tissue distribution and prognosis prediction in chronic kidney Disease patients
Lipid management in clinic is critical to the prevention and treatment of Chronic kidney disease (CKD), while the manifestations of lipid indicators vary in types and have flexible association with CKD prognosis.
