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Article
Open AccessEnhanced abscopal anti-tumor response via a triple combination of thermal ablation, IL-21, and PD-1 inhibition therapy
Despite the success of immune checkpoint inhibitors (ICIs) in treating solid tumors, lots of patients remain unresponsive to this therapy. Microwave ablation (MWA) stimulates systemic adaptive immunity against...
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Article
Open AccessInhibition of iRhom1 by CD44-targeting nanocarrier for improved cancer immunochemotherapy
The multifaceted chemo-immune resistance is the principal barrier to achieving cure in cancer patients. Identifying a target that is critically involved in chemo-immune-resistance represents an attractive stra...
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Article
Targeting Xkr8 via nanoparticle-mediated in situ co-delivery of siRNA and chemotherapy drugs for cancer immunochemotherapy
Activation of scramblases is one of the mechanisms that regulates the exposure of phosphatidylserine to the cell surface, a process that plays an important role in tumour immunosuppression. Here we show that c...
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Article
Open AccessImproving cancer immunotherapy by rationally combining oncolytic virus with modulators targeting key signaling pathways
Oncolytic viruses (OVs) represent a new class of multi-modal immunotherapies for cancer, with OV-elicited antitumor immunity being key to their overall therapeutic efficacy. Currently, the clinical effectivene...
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Article
Open AccessIL-36γ-armed oncolytic virus exerts superior efficacy through induction of potent adaptive antitumor immunity
In this study, we aimed to apply the cytokine IL-36γ to cancer immunotherapy by constructing new oncolytic vaccinia viruses (OV) expressing interleukin-36γ (IL-36γ-OVs), leveraging unique synergism between OV and...
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Article
Open AccessImmune suppressed tumor microenvironment by exosomes derived from gastric cancer cells via modulating immune functions
Gastric cancer is one of the leading causes of cancer-related death due to late diagnosis with high metastatic frequency. In this study, the impact of tumor secreted exosomes on immune function in the tumor en...
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Article
Open AccessB7-H3 promotes aerobic glycolysis and chemoresistance in colorectal cancer cells by regulating HK2
Accumulating evidence suggests that aerobic glycolysis is important for colorectal cancer (CRC) development. However, the underlying mechanisms have yet to be elucidated. B7-H3, an immunoregulatory protein, is...
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Article
Inhibition of the dipeptidyl peptidase DPP4 (CD26) reveals IL-33-dependent eosinophil-mediated control of tumor growth
Post-translational modification of chemokines mediated by the dipeptidyl peptidase DPP4 (CD26) has been shown to negatively regulate lymphocyte trafficking, and its inhibition enhances T cell migration and tum...
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Article
Open AccessVaccinia virus-mediated cancer immunotherapy: cancer vaccines and oncolytics
Cancer vaccines and oncolytic immunotherapy are promising treatment strategies with potential to provide greater clinical benefit to patients with advanced-stage cancer. In particular, recombinant vaccinia vir...
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Article
Inhibition of histone lysine-specific demethylase 1 elicits breast tumor immunity and enhances antitumor efficacy of immune checkpoint blockade
Immunotherapy strategies have been emerging as powerful weapons against cancer. Early clinical trials reveal that overall response to immunotherapy is low in breast cancer patients, suggesting that effective s...
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Article
Open AccessHigh mRNA expression level of IL-6R was associated with better prognosis for patients with ovarian cancer: a pooled meta-analysis
Interleukin-6 acts as both a pro-inflammatory cytokine and an anti-inflammatory myokine. IL-6/IL-6R signaling pathway, in particular, has been proposed to be a pivotal cytokine promoting ovarian cancer progres...
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Article
Interleukin-33 Expression does not Correlate with Survival of Gastric Cancer Patients
The aim of the study was to investigate IL-33 expression in gastric cancer (GC) and its association with the clinical characteristics and the prognosis. IL-33 protein in tumor and corresponding adjacent tissue...
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Article
Open AccessElastocaloric effect and superelastic stability in Ni–Mn–In–Co polycrystalline Heusler alloys: hysteresis and strain-rate effects
Controlling material hysteresis and working frequency variability are fundamentally important for refrigeration cycle efficiency and power density in solid-state cooling systems. For elastocaloric cooling, und...
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Article
Open AccessAn immunostimulatory dual-functional nanocarrier that improves cancer immunochemotherapy
Immunochemotherapy combines a chemotherapeutic agent with an immune-modulating agent and represents an attractive approach to improve cancer therapy. However, the success of immunochemotherapy is hampered by t...
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Article
Interleukin-33 in tumorigenesis, tumor immune evasion, and cancer immunotherapy
Interleukin-33 (IL-33) is a member of the IL-1 gene family and mainly expressed in the nucleus of tissue lining cells, stromal cells, and activated myeloid cells. IL-33 is considered a damage-associated molecu...
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Article
Mechanocaloric materials for solid-state cooling
This article reviews the up-to-date progress in mechanocaloric effect and materials near ambient temperature. For elastocaloric materials, we focus on directly measured temperature change and its entropy origi...
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Article
Open AccessEvaluation of tumor response to cytokine-induced killer cells therapy in malignant solid tumors
CIK cells therapy has been evaluated as an adoptive cell immunotherapy for cancer patients, but there still have not been any standardized systems for evaluating the antitumor efficacy yet. The WHO and RECIST ...
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Article
Open AccessCharacteristic analysis of α-fetoprotein-producing gastric carcinoma in China
α-Fetoprotein-producing gastric cancer (AFPGC) is a rare type of gastric cancer. The largest population of patients with AFPGC is found in China. In the present study, a total of 4,779 GC patients, including 3...
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Article
Open AccessCytokine-induced killer cells promote antitumor immunity
The number of immune cells, especially dendritic cells and cytotoxic tumor infiltrating lymphocytes (TIL), particularly Th1 cells, CD8 T cells, and NK cells is associated with increased survival of cancer pati...
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Article
Open AccessCAR/FoxP3-engineered T regulatory cells target the CNS and suppress EAE upon intranasal delivery
Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS). In the murine experimental autoimmune encephalomyelitis (EAE) model of MS, T regulatory (Treg) cell therapy has proved to b...
