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    Article

    Oridonin ameliorates inflammation-induced bone loss in mice via suppressing DC-STAMP expression

    Currently, dendritic cell-specific transmembrane protein (DC-STAMP), a multipass transmembrane protein, is considered as the master regulator of cell–cell fusion, which underlies the formation of functional mu...

    Bin-hua Zou, Yan-hui Tan, Wen-de Deng, Jie-huang Zheng… in Acta Pharmacologica Sinica (2021)

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    Article

    Artesunate attenuates LPS-induced osteoclastogenesis by suppressing TLR4/TRAF6 and PLCγ1-Ca2+-NFATc1 signaling pathway

    In chronic infectious diseases caused by gram-negative bacteria, such as osteomyelitis, septic arthritis, and periodontitis, osteoclastic activity is enhanced with elevated inflammation, which disturbs the bon...

    **ang-zhou Zeng, Yue-yang Zhang, Qin Yang, Song Wang… in Acta Pharmacologica Sinica (2020)